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Resiquimod

Cat. No. 4536 2 篇引用文献 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Toll-like receptor 7 (TLR7) agonist
别名： R 848
化学名： 1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论 (1)
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Resiquimod

Resiquimod is a toll-like receptor 7 (TLR7) agonist. Induces upregulation of IL-6, IL-12, IFN-γ and iNOS expression in mouse bone marrow-derived macrophages (BMMs). Inhibits RANKL-induced osteoclast differentiation in mouse BMMs and human peripheral blood monocytes. Also promotes the differentiation of MDSCs into macrophages and dendritic cells. Proinflammatory and antiviral.

化合物库 for Resiquimod

Resiquimod is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Resiquimod

分子量 314.38
公式 C17H22N4O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 144875-48-9
PubChem ID 159603
InChI Key BXNMTOQRYBFHNZ-UHFFFAOYSA-N
Smiles NC1=C3C(N(CC(C)(O)C)C(COCC)=N3)=C2C(C=CC=C2)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Resiquimod

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 31.44 100
ethanol 6.29 20

制备储备液 for Resiquimod

以下数据基于产品分子量 314.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.18 mL 15.9 mL 31.81 mL
5 mM 0.64 mL 3.18 mL 6.36 mL
10 mM 0.32 mL 1.59 mL 3.18 mL
50 mM 0.06 mL 0.32 mL 0.64 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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产品说明书 for Resiquimod

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Resiquimod

参考文献是支持产品生物活性的出版物。

Dockrell and Kinghorn (2001) Imiquimod and resiquimod as novel immunomodulators. J.Antimicrob.Chemother. 48 751 PMID: 11733457

Miyamoto et al (2012) R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts. Cytotechnology. 64 331 PMID: 22358541

Wagner et al (1999) Modulation of TH1 and Th2 cytokine production with the immune response modifiers, R-848 and imiq. Cell Immunol. 191 10 PMID: 9918682

Lee et al (2014) Resiquimod, a TLR7/8 agonist, promotes differentiation of myeloid-derived suppressor cells into macrophages and dendritic cells. Arch.Pharm.Res. 37 1234 PMID: 24748512

If you know of a relevant reference for Resiquimod, please let us know.

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关键词: Resiquimod, Resiquimod supplier, proinflammatory, toll, like, receptors, ligands, agonists, TLR7, cytokines, interferons, interleukins, R848, R_848, myeloid-derived, suppressor, cells, MDSCs, tumor, microenvironment, R, 848, Toll-like, Receptors, Non-selective, Antivirals, 4536, Tocris Bioscience

2 篇 Resiquimod 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Resiquimod 的部分引用包括：

Ming et al (2022) Robust induction of B cell and T cell responses by a third dose of inactivated SARS-CoV-2 vaccine. Cell Discov 8 10 PMID: 35102140

Yumi et al (2022) Imprime PGG Enhances Anti-Tumor Effects of Tumor-Targeting, Anti-Angiogenic, and Immune Checkpoint Inhibitor Antibodies. Front Oncol 12 869078 PMID: 35692755

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Resiquimod 的评论

平均评分: 5 (Based on 1 Review.)

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Good, stores well.
By Scott Scarneo on 02/06/2019
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： BMDM

Worked well for macrophages and got the desired result by TNF production.

review image

Pathways for Resiquimod

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.