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RF 9

Cat. No. 3672 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective NPFF1 and NPFF2 antagonist
纯度： ≥95% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for RF 9

RF 9 is a selective NPFF receptor antagonist (Ki values are 58 and 75 nM at hNPFF1 and hNPFF2 receptors respectively). Displays selectivity over several related receptors including NPY Y1 GPR10, GPR54, GPR103 and the opioid receptors. Blocks NPFF-induced hypothermia and increases in atrial blood pressure and heart rate, and prevents opioid-induced tolerance associated with hyperalgesia in vivo.

技术数据 for RF 9

分子量 482.62
公式 C26H38N6O3
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 876310-60-0
PubChem ID 53320361
InChI Key UMKHUSRDQFQHAK-RNJMTYCLSA-N
Smiles O=C(N[C@H]([C@](N[C@H](C(N)=O)CC4=CC=CC=C4)=O)CCCNC(N)=N)C1(CC(C3)C2)CC3CC2C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RF 9

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.83 10

制备储备液 for RF 9

以下数据基于产品分子量 482.62。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 20.72 mL 103.6 mL 207.2 mL
0.5 mM 4.14 mL 20.72 mL 41.44 mL
1 mM 2.07 mL 10.36 mL 20.72 mL
5 mM 0.41 mL 2.07 mL 4.14 mL

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产品说明书 for RF 9

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for RF 9

参考文献是支持产品生物活性的出版物。

Wang et al (2008) Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice. Peptides 29 1183 PMID: 18406009

Simonin et al (2006) RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proc.Natl.Acad.Sci.USA 103 466

Fang et al (2008) Inhibition of neuropeptide FF (NPFF)-induced hypothermia and anti-morphine analgesia by RF9, a new selective NPFF receptors antagonist. Regul.Peptides 147 45

If you know of a relevant reference for RF 9, please let us know.

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关键词: RF 9, RF 9 supplier, Selective, NPFF1, NPFF2, antagonists, npffr1, npffr2, Neuropeptide, FF, AF, Receptors, FF/AF, RF9, neuropeptides, 3672, Tocris Bioscience

3 篇 RF 9 的引用文献

引用文献是使用了 Tocris 产品的出版物。 RF 9 的部分引用包括：

Jian et al (2023) RFRP-3 Influences Apoptosis and Steroidogenesis of Yak Cumulus Cells and Compromises Oocyte Meiotic Maturation and Subsequent Developmental Competence. Int J Mol Sci 24 PMID: 37108163

Lee et al (2017) Genetic and neuronal regulation of sleep by neuropeptide VF. Elife 6 PMID: 29106375

Alsaqati et al (2014) Novel vasocontractile role of the P2Y14 receptor: characterization of its signalling in porcine isolated pancreatic arteries. Br J Pharmacol 171 701 PMID: 24138077

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