RN 1734

Cat. No. 3746 14 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective TRPV4 antagonist

化学名： 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide

引用文献 (14)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for RN 1734

RN 1734 is a selective TRPV4 antagonist (IC₅₀ values are 2.3, 3.2 and 5.9 μM for hTRPV4, rTRPV4 and mTRPV4 receptors respectively). Displays selectivity for TRPV4 over other TRP channels (IC₅₀ values are 2.3, >30, >30 and >100 μM for TRPV4, TRPV3, TRPM8 and TRPV1 respectively). Blocks TRPV4-mediated arteriole vasodilation and increases myogenic tone ex vivo.

化合物库 for RN 1734

RN 1734 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for RN 1734

分子量	353.31
公式	C₁₄H₂₂Cl₂N₂O₂S
储存	Store at +4°C
CAS Number	946387-07-1
PubChem ID	3601086
InChI Key	IHYZMEAZAIFMTN-UHFFFAOYSA-N
Smiles	CC(C)NCCN(C(C)C)S(C1=C(Cl)C=C(Cl)C=C1)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RN 1734

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	35.33	100
	ethanol	17.67	50

制备储备液 for RN 1734

以下数据基于产品分子量 353.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.83 mL	14.15 mL	28.3 mL
5 mM	0.57 mL	2.83 mL	5.66 mL
10 mM	0.28 mL	1.42 mL	2.83 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

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产品说明书 for RN 1734

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RN 1734

参考文献是支持产品生物活性的出版物。

Vincent et al (2009) Identification and characterization of novel TRPV4 modulators. Biochem.Biophys.Res.Comms. 389 490 PMID: 19737537

Bagher et al (2012) Low intravascular pressure activates endothelial cell TRPV4 channels, local Ca2+ events, and IKCa channels, reducing arteriolar tone. Proc.Natl.Acad.Sci.U.S.A. 109 18174 PMID: 23071308

If you know of a relevant reference for RN 1734, please let us know.

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