RN 9893 hydrochloride

Cat. No. 5678 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective TRPV4 antagonist

化学名： N-[4-[[4-(1-Methylethyl)-1-piperazinyl]sulfonyl]phenyl]-2-nitro-4-(trifluoromethyl)benzamide hydrochloride

纯度： ≥99% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for RN 9893 hydrochloride

RN 9893 hydrochloride is a potent and selective TRPV4 antagonist (IC₅₀ values are 320, 420 and 660 nM for mouse, human and rat channels, respectively). Exhibits >15-fold selectivity for TRPV4 over TRPV1, TRPV3 and TRPM8, and a panel of 54 other common biological targets. Orally bioavailable.

化合物库 for RN 9893 hydrochloride

RN 9893 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for RN 9893 hydrochloride

分子量	536.95
公式	C₂₁H₂₃F₃N₄O₅S.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	2109450-40-8
PubChem ID	121513879
InChI Key	ULUOUAGDTULBRZ-UHFFFAOYSA-N
Smiles	O=C(NC2=CC=C(S(N3CCN(C(C)C)CC3)(=O)=O)C=C2)C1=CC=C(C(F)(F)F)C=C1[N+]([O-])=O.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RN 9893 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	53.69	100

制备储备液 for RN 9893 hydrochloride

以下数据基于产品分子量 536.95。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.86 mL	9.31 mL	18.62 mL
5 mM	0.37 mL	1.86 mL	3.72 mL
10 mM	0.19 mL	0.93 mL	1.86 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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产品说明书 for RN 9893 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RN 9893 hydrochloride

参考文献是支持产品生物活性的出版物。

Wei et al (2015) Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg.Med.Chem.Lett. 25 4011 PMID: 26235950

If you know of a relevant reference for RN 9893 hydrochloride, please let us know.

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关键词: RN 9893 hydrochloride, RN 9893 hydrochloride supplier, RN9893, hydrochloride, potent, selective, TRPV4, transient, receptors, potential, channels, orally, bioavailable, 1803003-68-0, TRPV, 5678, Tocris Bioscience

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