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Ro 106-9920

Cat. No. 1778 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1778 has been discontinued.

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说明： Inhibitor of NF-κB activation
化学名： 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine
纯度： ≥99% (HPLC)
说明书
引用文献 (4)
评论
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Ro 106-9920

Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.

技术数据 for Ro 106-9920

分子量 245.26
公式 C10H7N5OS
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 62645-28-7
PubChem ID 3906779
InChI Key JFSXSNSCPNFCDM-UHFFFAOYSA-N
Smiles O=S(C1=CC=CC=C1)C1=NN2N=NN=C2C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Ro 106-9920

参考文献是支持产品生物活性的出版物。

Conalty et al (1976) Anticancer agents. XII. Pyridazine and benzodiazine derivatives. Proc.R.Ir.Acad.B. 76 151 PMID: 967871

Swinney et al (2002) A small molecule ubiquitination inhibitor blocks NF-κB-dependent cytokine expression in cells and rats. J.Biol.Chem. 277 23573 PMID: 11950839

Baginski et al (2002) Glucocorticoid modulation of MUC5AC secretion in H292 cells. Am.Soc.Cell Biol.Abstr. 765

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关键词: Ro 106-9920, Ro 106-9920 supplier, inhibitors, inhibits, NF-κB, NF-kappaB, NF-kB, activation, Transcription, Factors, Nuclear, Factor, Kappa, B, Ro106-9920, NF-kB/IkB, 1778, Tocris Bioscience

4 篇 Ro 106-9920 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ro 106-9920 的部分引用包括：

Siew et al (2019) Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease. Nat Commun 10 3473 PMID: 31375685

Huang et al (2015) ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells. J Inflamm (Lond) 12 31 PMID: 25914608

Lapponi et al (2013) Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs. J Pharmacol Exp Ther 345 430 PMID: 23536315

Marinelli et al (2015) Ligand engagement of Toll-like receptors regulates their expression in cortical microglia and astrocytes. PLoS One 12 244 PMID: 26714634

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Pathways for Ro 106-9920

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.