Ro 1138452 hydrochloride

Name: Ro 1138452 hydrochloride
Brand: Tocris Bioscience
SKU: 4268

Cat. No. 4268 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4268 has been discontinued.

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说明： Selective prostacyclin IP receptor antagonist

化学名： 4,5-Dihydro-N-[4-[[4-(1-methylethoxy)phenyl]methyl]phenyl]-1H-imidazol-2-amine hydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Ro 1138452 hydrochloride

Ro 1138452 hydrochloride is a selective prostacyclin IP receptor antagonist (pK_i = 8.3). Exhibits no affinity at other prostanoid receptors (EP_1-4, FP and TP) in a radioligand binding assay. Demonstrates analgesic activity in rats. Orally bioavailable.

化合物库 for Ro 1138452 hydrochloride

Ro 1138452 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Ro 1138452 hydrochloride

分子量	345.87
公式	C₁₉H₂₃N₃O.HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
PubChem ID	91826074
InChI Key	OYPSAMWVIBGRMV-UHFFFAOYSA-N
Smiles	CC(C)OC1=CC=C(CC2=CC=C(NC3=NCCN3)C=C2)C=C1.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Ro 1138452 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ro 1138452 hydrochloride

参考文献是支持产品生物活性的出版物。

Clark et al (2004) Discovery and SAR development of 2-(phenylamino) imidazolines as prostacyclin receptor antagonists. Bioorg.Med.Chem.Lett. 14 1053 PMID: 15013022

Jones et al (2006) Investigation of the prostacyclin (IP) receptor antagonist RO1138452 on isolated blood vessel and platelet preparations. Br.J.Pharmacol. 149 110 PMID: 16880763

Bley et al (2006) RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists. Br.J.Pharmacol. 147 335 PMID: 16331286

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关键词: Ro 1138452 hydrochloride, Ro 1138452 hydrochloride supplier, Ro1138452, hydrochloride, supplier, IP, receptors, antagonists, prostanoid, prostaglandins, prostacyclins, eicosanoids, analgesic, CAS, 221529-58-4, Prostanoid, Receptors, 4268, Tocris Bioscience

1 篇 Ro 1138452 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ro 1138452 hydrochloride 的部分引用包括：

Maria Dulce et al (2022) Vascular Effects of Polyphenols from Agrimonia eupatoria L. and Role of Isoquercitrin in Its Vasorelaxant Potential in Human Arteries. Pharmaceuticals (Basel) 15 PMID: 35631463