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Ro 20-1724

Cat. No. 0415 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： PDE4 inhibitor
化学名： 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone
纯度： ≥99% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ro 20-1724

Ro 20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM).

化合物库 for Ro 20-1724

Ro 20-1724 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Ro 20-1724

分子量 278.35
公式 C15H22N2O3
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 29925-17-5
PubChem ID 5087
InChI Key PDMUULPVBYQBBK-UHFFFAOYSA-N
Smiles CCCCOC1=CC(CC2CNC(=O)N2)=CC=C1OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ro 20-1724

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 27.84 100
DMSO 27.84 100

制备储备液 for Ro 20-1724

以下数据基于产品分子量 278.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.59 mL 17.96 mL 35.93 mL
5 mM 0.72 mL 3.59 mL 7.19 mL
10 mM 0.36 mL 1.8 mL 3.59 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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产品说明书 for Ro 20-1724

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Ro 20-1724

参考文献是支持产品生物活性的出版物。

Nicholson et al (1991) Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS 12 19 PMID: 1848733

Reeves et al (1987) The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Biochem.J. 241 535 PMID: 3036066

Soderling et al (1998) Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc.Natl.Acad.Sci.U.S.A. 95 8991 PMID: 9671792

If you know of a relevant reference for Ro 20-1724, please let us know.

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关键词: Ro 20-1724, Ro 20-1724 supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, Ro20-1724, 0415, Tocris Bioscience

3 篇 Ro 20-1724 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ro 20-1724 的部分引用包括：

Peters et al (2007) Evaluation of cellular dielectric spectroscopy, a whole-cell, label-free technology for drug discovery on Gi-coupled GPCRs. J Biomol Screen 12 312 PMID: 17307886

Winger et al (2014) Rapid remodeling of tight junctions during paracellular diapedesis in a human model of the blood-brain barrier. J Immunol 193 2427 PMID: 25063869

Zhong et al (2012) Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference. Neuropsychopharmacology 37 2377 PMID: 22713909

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