Ro 3306

Cat. No. 4181 20 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Cdk1 inhibitor

化学名： 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone

纯度： ≥98% (HPLC)

引用文献 (20)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Ro 3306

Ro 3306 is an ATP-competitive cyclin-dependent kinase 1 (cdk1) inhibitor (K_i values range from 35 to 240 nM depending on cdk1 binding partner). Also reported to inhibit other cdks (K_i values are 0.89-1.32, 0.03 and >2 μM for cdk2, cdk3 and cdk4, respectively). Induces G2/M phase cell cycle arrest and apoptosis. Downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). RO 3306 also improves homology-directed repair (HDR) -mediated gene editing in hematopoietic stem and progenitor cells.

化合物库 for Ro 3306

Ro 3306 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Kinase Inhibitor Library and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Ro 3306

分子量	351.45
公式	C₁₈H₁₃N₃OS₂
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	872573-93-8
PubChem ID	11631681
InChI Key	XOLMRFUGOINFDQ-YBEGLDIGSA-N
Smiles	O=C2/C(SC(NCC3=CC=CS3)=N2)=C/C1=CC=C(N=CC=C4)C4=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ro 3306

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	7.03	20 温和加热

制备储备液 for Ro 3306

以下数据基于产品分子量 351.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	14.23 mL	71.13 mL	142.27 mL
1 mM	2.85 mL	14.23 mL	28.45 mL
2 mM	1.42 mL	7.11 mL	14.23 mL
10 mM	0.28 mL	1.42 mL	2.85 mL

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产品说明书 for Ro 3306

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ro 3306

参考文献是支持产品生物活性的出版物。

et al (2006) Selective Proc.Natl.Acad.Sci. 10660 et al (2018) How selective J.Med.Chem. 9105 Kojima RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. 100 PMID: 19385969

ght">Vassilev small-molecule inhibitor reveals critical mitotic functions of human CDK1. 103 PMID: 16818887

ght">Yu mediator of DNA damage checkpoint 1 during mitotic DNA damage. 72 PMID: 22962268

ght">Jorda are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? 61 PMID: 30234987

ght">Azhagiri gene-editing approaches for hematopoietic stem and progenitor cell gene therapy. 12 PMID: 34503562 you know of a relevant reference for Ro 3306, please let us know.

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