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RO 5263397 hydrochloride

Cat. No. 6833 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent TA1 receptor agonist
化学名： (4S)-4-(3-Fluoro-2-methylphenyl)-4,5-dihydro-2-oxazolamine hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for RO 5263397 hydrochloride

RO 5263397 hydrochloride is a potent trace amine 1 (TA1) receptor agonist (EC50 values are 0.12, 35 and 17-85 nM for mouse, rat and human receptors, respectively). Increases wakefulness and reduces REM and NREM sleep duration in wild type mice. Inhibits spontaneous locomotor activity in dopamine transport (DAT) knockout mice.

化合物库 for RO 5263397 hydrochloride

RO 5263397 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for RO 5263397 hydrochloride

分子量 230.67
公式 C10H11FN2O.HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
InChI Key JFAYMXKBMDRFHY-SBSPUUFOSA-N
Smiles CC1=C([C@H]2COC(N)=N2)C=CC=C1F.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RO 5263397 hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 23.07 100
water 23.07 100

制备储备液 for RO 5263397 hydrochloride

以下数据基于产品分子量 230.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.34 mL 21.68 mL 43.35 mL
5 mM 0.87 mL 4.34 mL 8.67 mL
10 mM 0.43 mL 2.17 mL 4.34 mL
50 mM 0.09 mL 0.43 mL 0.87 mL

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产品说明书 for RO 5263397 hydrochloride

分析证书/产品说明书
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参考文献 for RO 5263397 hydrochloride

参考文献是支持产品生物活性的出版物。

Espinoza et al (2018) Biochemical and functional characterization of the trace amine-associated receptor 1 (TAAR1) agonist RO5263397. Front.Pharmacol. 9 645 PMID: 29977204

Galley et al (2015) Discovery and characterization of 2-aminooxazolines as highly potent, selective, and orally active TAAR1 agonists. ACS.Med.Chem.Letts. 7 192 PMID: 26985297

Schwartz et al (2017) Trace amine-associated receptor 1 regulates wakefulness and EEG spectral composition. Neuropsychopharmacology. 42 1305 PMID: 27658486

If you know of a relevant reference for RO 5263397 hydrochloride, please let us know.

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关键词: RO 5263397 hydrochloride, RO 5263397 hydrochloride supplier, Trace, amine, associated, receptor, 1, agonists, agonism, TAR, TA1, TAAR1, locomotion, waking, REM, NREM, sleep, Amine, Receptor, 6833, Tocris Bioscience

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