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Submit ReviewRo 8-4304 hydrochloride
说明： GluN2B-selective NMDA antagonist
化学名： 4-[3-[4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1(2H)-pyridinyl]-2-hydroxypropoxy]benzamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Ro 8-4304 hydrochloride
NMDA receptor antagonist (IC50 = 0.4 μM) that displays > 100 fold selectivity for GluN2B (formally NR2B) containing receptors over GluN2A (formally NR2A) containing receptors. Exhibits an activity-dependent mechanism of NMDA antagonism and is competitive with respect to spermine (Cat. No. 0958).
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
技术数据 for Ro 8-4304 hydrochloride
| 分子量 | 406.88 |
| 公式 | C21H23FN2O3.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 1312991-77-7 |
| PubChem ID | 11957680 |
| InChI Key | MQOXWHKUQOFFJW-UHFFFAOYSA-N |
| Smiles | NC(C1=CC=C(OCC(O)CN2CCC(C3=CC=C(F)C=C3)=CC2)C=C1)=O.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Ro 8-4304 hydrochloride
参考文献 for Ro 8-4304 hydrochloride
参考文献是支持产品生物活性的出版物。
Kew et al (1998) State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist. Br.J.Pharmacol. 123 463 PMID: 9504387
Kew and Kemp (1998) An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones. J.Physiol. 512 17 PMID: 9729614
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