RS 23597-190 hydrochloride

Cat. No. 0728 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： 5-HT₄ antagonist

化学名： 3-(Piperidin-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride

引用文献 (5)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for RS 23597-190 hydrochloride

RS 23597-190 hydrochloride is a high affinity, selective competitive antagonist at 5-HT₄ receptors.

许可信息

Sold with the permission of Roche Bioscience

技术数据 for RS 23597-190 hydrochloride

分子量	363.28
公式	C₁₆H₂₃ClN₂O₃.HCl
储存	Store at RT
CAS Number	149719-06-2
PubChem ID	182592
InChI Key	QLZLBYYNMGQIAR-UHFFFAOYSA-N
Smiles	Cl.COC1=CC(N)=C(Cl)C=C1C(=O)OCCCN1CCCCC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for RS 23597-190 hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water		100

制备储备液 for RS 23597-190 hydrochloride

以下数据基于产品分子量 363.28。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.75 mL	13.76 mL	27.53 mL
5 mM	0.55 mL	2.75 mL	5.51 mL
10 mM	0.28 mL	1.38 mL	2.75 mL
50 mM	0.06 mL	0.28 mL	0.55 mL

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产品说明书 for RS 23597-190 hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for RS 23597-190 hydrochloride

参考文献是支持产品生物活性的出版物。

Eglen et al (1993) RS 23597-190: a potent and selective 5-HT₄ receptor antagonist. Br.J.Pharmacol. 110 119 PMID: 8220871

Eglen et al (1995) Central 5-HT₄ receptors. TiPS 16 391 PMID: 8578609

If you know of a relevant reference for RS 23597-190 hydrochloride, please let us know.

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关键词: RS 23597-190 hydrochloride, RS 23597-190 hydrochloride supplier, 5-HT4, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT, RS23597-190, hydrochloride, 0728, Tocris Bioscience

5 篇 RS 23597-190 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 RS 23597-190 hydrochloride 的部分引用包括：

Du et al (2015) Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J 29 2194 PMID: 25667222

Kato et al (2006) Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats. J Neurosci 26 1787 PMID: 16467527

Xiang et al (2005) Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes. J Neurophysiol 93 1145 PMID: 15738272

Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572

Huang and Kandel (2007) 5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala. J Pharmacol Exp Ther 27 3111 PMID: 17376972

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.