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Submit ReviewRS 67506 hydrochloride
说明： 5-HT4 partial agonist
化学名： 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride
生物活性 for RS 67506 hydrochloride
RS 67506 hydrochloride is a potent and selective 5-HT4 partial agonist, with a pKi of 8.8 at 5-HT4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.
许可信息
Sold with the permission of Roche Bioscience
技术数据 for RS 67506 hydrochloride
| 分子量 | 454.41 |
| 公式 | C18H28ClN3O4S.HCl |
| 储存 | Store at RT |
| CAS Number | 168986-61-6 |
| PubChem ID | 133075 |
| InChI Key | GFWKWEHKHLTRRF-UHFFFAOYSA-N |
| Smiles | Cl.COC1=C(C=C(Cl)C(N)=C1)C(=O)CCC1CCN(CCNS(C)(=O)=O)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for RS 67506 hydrochloride
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参考文献 for RS 67506 hydrochloride
参考文献是支持产品生物活性的出版物。
Eglen et al (1995) Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br.J.Pharmacol. 115 1387 PMID: 8564196
Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391 PMID: 8578609
Fontana et al (1997) The effects of novel, selective 5-hydroxytryptamine (5HT)4 ligands in rat spatial navigation. Neuropharmacology 36 689 PMID: 9225295
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关键词: RS 67506 hydrochloride, RS 67506 hydrochloride supplier, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, RS67506, hydrochloride, 0990, Tocris Bioscience
1 篇 RS 67506 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 RS 67506 hydrochloride 的部分引用包括：
Garavaglia et al (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci 11 7 PMID: 20085655
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.