(RS)-(±)-Sulpiride

Name: ( RS )-(±)-Sulpiride
Brand: Tocris Bioscience
SKU: 0894
Rating: 4 (2 reviews)

Cat. No. 0894 7 篇引用文献 2 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Standard selective D₂-like antagonist

化学名： (RS)-(±)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxybenzamide

纯度： ≥98% (HPLC)

说明书

引用文献 (7)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (RS)-(±)-Sulpiride

(RS)-(±)-Sulpiride is a standard D₂-like dopamine receptor antagonist.

S-enantiomer also available.

化合物库 for (RS)-(±)-Sulpiride

(RS)-(±)-Sulpiride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for (RS)-(±)-Sulpiride

分子量	341.42
公式	C₁₅H₂₃N₃O₄S
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	15676-16-1
PubChem ID	5355
InChI Key	BGRJTUBHPOOWDU-UHFFFAOYSA-N
Smiles	CCN1CCCC1CNC(=O)C1=C(OC)C=CC(=C1)S(N)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (RS)-(±)-Sulpiride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	34.14	100

制备储备液 for (RS)-(±)-Sulpiride

以下数据基于产品分子量 341.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.93 mL	14.64 mL	29.29 mL
5 mM	0.59 mL	2.93 mL	5.86 mL
10 mM	0.29 mL	1.46 mL	2.93 mL
50 mM	0.06 mL	0.29 mL	0.59 mL

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产品说明书 for (RS)-(±)-Sulpiride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (RS)-(±)-Sulpiride

参考文献是支持产品生物活性的出版物。

Seeman and Van Tol (1993) DA D₄ receptors bind inactive (+)-aporphines, suggesting neuroleptic role. Sulpiride not stereoselective. Eur.J.Pharmacol. 233 173 PMID: 8097160

Seeman and Van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991

Merck Index 12 9163

If you know of a relevant reference for (RS)-(±)-Sulpiride, please let us know.

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关键词: (RS)-(±)-Sulpiride, (RS)-(±)-Sulpiride supplier, selective, D2-like, antagonists, Dopamine, Non-Selective, Receptors, dopaminergic, Non-selective, 0894, Tocris Bioscience

7 篇 (RS)-(±)-Sulpiride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (RS)-(±)-Sulpiride 的部分引用包括：

Shin et al (2011) Exposure to extremely low frequency magnetic fields induces fos-related antigen-immunoreactivity via activation of DArgic d1 receptor. Neuropsychopharmacology 20 130 PMID: 22110371

Leyrer-Jackson (2017) Subtype-specific effects of DArgic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex. Physiol Rep 5 e13499 PMID: 29150590

Huang (2018) DA D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice. Invest Ophthalmol Vis Sci 59 2623 PMID: 29847669

Zhang et al (2018) DA Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs. Invest Ophthalmol Vis Sci 59 4441 PMID: 30193315

Matsui and Alvarez (2018) Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin. Cell Rep 23 3852 PMID: 29949769

Holroyd et al (2015) Loss of feedback inhibition via D2 autoreceptors enhances acquisition of cocaine taking and reactivity to drug-paired cues. Brain 40 1495 PMID: 25547712

Zhang et al (2013) Sucrose produces withdrawal and DA-sensitive reinforcing effects in planarians. Physiol Behav 112-113 8 PMID: 23415661

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Inhibition of Synaptic Transmission in the VP.

By Anonymous on 02/02/2020

分析类型： In Vivo

种属： Mouse

sulpiride (1 μM)

PMID: 29949769

Sulpiride reverses quinpirole effects on dopamine release.

By Anonymous on 03/28/2018

分析类型： Ex Vivo

种属： Mouse

In voltammetry experiments measuring evoked dopamine release, quinpirole was used to activate D2 receptors to inhibit dopamine release. Sulpiride (600 nM) was applied afterward to reverse quinpirole effects.

We mix sulpiride at 2mM in ethanol. It goes into solution well.

该领域的文献

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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