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Rupintrivir

Cat. No. 6414 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6414 has been discontinued.

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说明： Potent and selective irreversible human rhinovirus 3Cpro inhibitor
化学名： Ethyl (2E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-1,4-dioxoheptyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Rupintrivir

Rupintrivir is a potent and selective irreversible human rhinovirus (HRV) 3C protease inhibitor (EC50 = 5 nM). Exhibits no significant inhibition against a variety of serine and cysteine proteases. Inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

技术数据 for Rupintrivir

分子量 598.66
公式 C31H39FN4O7
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 223537-30-2
PubChem ID 6440352CAY
InChI Key CAYJBRBGZBCZKO-BHGBQCOSSA-N
Smiles O=C(C1=NOC(C)=C1)N[C@@H](C(C)C)C(C[C@@H](CC2=CC=C(F)C=C2)C(N[C@H](/C=C/C(OCC)=O)C[C@@H]3CCNC3=O)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Rupintrivir

参考文献是支持产品生物活性的出版物。

Patick et al (1999) In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob.Agents Chemother. 43 2444 PMID: 10508022

Dragovich et al (1999) Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J.Med.Chem. 42 1203 PMID: 10197964

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关键词: Rupintrivir, Rupintrivir supplier, HRV, inhibits, inhibitors, Potent, selective, irreversible, human, rhinovirus, 3C, protease, and, 3CL, Proteases, Other, Antivirals, 6414, Tocris Bioscience

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