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Ryuvidine

Cat. No. 2609 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： SETD8 inhibitor; also CDK4 inhibitor
化学名： 2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ryuvidine

Ryuvidine is an inhibitor of SETD8 protein lysine methyltransferase (PKMT) (IC50 = 0.5 μM); suppresses H4K20 monomethylation in vitro. Also inhibits cyclin-dependent kinase (CDK) 4 (IC50 = 6.0 μM at CDK4/cyclin D1). Induces S phase accumulation in HEK293T cells. Cytotoxic against a range of human cancer cells.

化合物库 for Ryuvidine

Ryuvidine is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Ryuvidine

分子量 284.33
公式 C15H12N2O2S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 265312-55-8
PubChem ID 481747
InChI Key HFPLHASLIOXVGS-UHFFFAOYSA-N
Smiles CC1=NC2=C(S1)C(=O)C=C(NC1=CC=C(C)C=C1)C2=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ryuvidine

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 5.69 20
ethanol 1.42 5

制备储备液 for Ryuvidine

以下数据基于产品分子量 284.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 17.59 mL 87.93 mL 175.85 mL
1 mM 3.52 mL 17.59 mL 35.17 mL
2 mM 1.76 mL 8.79 mL 17.59 mL
10 mM 0.35 mL 1.76 mL 3.52 mL

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产品说明书 for Ryuvidine

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Ryuvidine

参考文献是支持产品生物活性的出版物。

Ryu et al (2000) 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents. Bioorg.Med.Chem.Lett. 10 461 PMID: 10743948

Blum et al (2014) Small-molecule inhibitors of SETD8 with cellular activity. ASC.Chem.Biol. [Epub ahead of print] 9 2471 PMID: 25137013

If you know of a relevant reference for Ryuvidine, please let us know.

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关键词: Ryuvidine, Ryuvidine supplier, Cyclin-dependent, protein, kinase, 4, cdk4, inhibitors, SETD8, lysine, methyltransferases, inhibits, SPS8I2, Kinase, Lysine, Methyltransferases, Other, CDK4, Subfamily, 2609, Tocris Bioscience

1 篇 Ryuvidine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ryuvidine 的部分引用包括：

FitzGerald et al (2014) A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response. PLoS One 9 e98891 PMID: 24902048

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