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S 18886

Cat. No. 5568 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent thromboxane A2 (TP) antagonist
别名： terutroban
化学名： (6R)-6-[[(4-Chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for S 18886

S 18886 is a potent thromboxane A2 (TP) inhibitor (IC50 = 16.4 nM). Inhibits U 46619 (Cat. No. 1932) induced human platelet aggregation and contraction of isolated rabbit saphenous vein in vitro. Also inhibits U 46619 induced increase in tracheal pressure in guinea pigs. Orally available.

化合物库 for S 18886

S 18886 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for S 18886

分子量 407.91
公式 C20H22ClNO4S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 165538-40-9
PubChem ID 9938840
InChI Key HWEOXFSBSQIWSY-MRXNPFEDSA-N
Smiles CC1=CC=C(C[C@H](NS(C2=CC=C(Cl)C=C2)(=O)=O)CC3)C3=C1CCC(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for S 18886

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 40.79 100
ethanol 8.16 20 温和加热

制备储备液 for S 18886

以下数据基于产品分子量 407.91。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.26 mL 24.52 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.25 mL 1.23 mL 2.45 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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参考文献 for S 18886

参考文献是支持产品生物活性的出版物。

Cimetière et al (1998) Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists. Bioorg.Med.Chem.Lett. 8 1375 PMID: 9871769

Wang et al (2014) Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. ACS Med.Chem.Lett. 5 1015 PMID: 25221659

If you know of a relevant reference for S 18886, please let us know.

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关键词: S 18886, S 18886 supplier, S18886, terutroban, thromboxane, A2, antagonist, platelet, aggregation, orally, availalble, prostanoids, inhibitors, inhibits, Prostanoid, Receptors, 5568, Tocris Bioscience

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