S 24795

Cat. No. 3518 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： α7 nAChR partial agonist

化学名： 2-[2-(4-Bromophenyl)-2-oxoethyl]-1-methylpyridinium iodide

纯度： ≥99% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for S 24795

S 24795 is a partial agonist of α7 nAChR. Improves mnemonic function in aged mice for the treatment of aging-related memory disturbances. Displays more efficient memory-enhancing effects than memantine (Cat. No. 0773) in Alzheimer's disease mouse models.

技术数据 for S 24795

分子量	418.07
公式	C₁₄H₁₃BrINO
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	304679-75-2
PubChem ID	9888248
InChI Key	LERUHBBUGAOYOD-UHFFFAOYSA-M
Smiles	BrC1=CC=C(C(CC2=[N+](C)C=CC=C2)=O)C=C1.[I-]

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for S 24795

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	4.18	10 温和加热
	DMSO	41.81	100

制备储备液 for S 24795

以下数据基于产品分子量 418.07。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.39 mL	11.96 mL	23.92 mL
5 mM	0.48 mL	2.39 mL	4.78 mL
10 mM	0.24 mL	1.2 mL	2.39 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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产品说明书 for S 24795

分析证书/产品说明书

化学品安全技术说明书

参考文献 for S 24795

参考文献是支持产品生物活性的出版物。

Lagostena et al (2008) The partial α7 nicotine acetylcholine receptor agonist S 24795 enhances long-term potentiation at CA3-CA1 synapses in the adult mouse hippocampus. Neuropharmacology 54 676 PMID: 18187166

Marighetto et al (2008) Comparative effects of the α7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice. Psychopharmacology. 197 499 PMID: 18265960

Beracochea et al (2008) Improvement of contextual memory by S 24795 in aged mice: comparison with Mem.. Psychopharmacology 196 555 PMID: 18034231

If you know of a relevant reference for S 24795, please let us know.

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关键词: S 24795, S 24795 supplier, S24795, partial, agonist, a7, nAChR, nicotinic, acetylcholine, receptor, α7, agonists, Nicotinic, (a7), Receptors, 3518, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.