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说明： Potent and selective NPY Y5 receptor antagonist
化学名： 1-Benzoyl-2-[[trans-4-[[[[2-nitro-4-(trifluoromethyl)phenyl]sulfonyl]amino]methyl]cyclohexyl]carbonyl]hydrazine
纯度： ≥98% (HPLC)
生物活性 for S 25585
Potent neuropeptide Y (NPY) Y5 receptor antagonist (IC50 values are 5.4, > 1000, > 10 000 and > 10 000 nM at Y5, Y1, Y2 and Y4 receptors respectively) that displays no affinity for a wide range of other receptors. Does not produce a conditioned taste aversion, suppress sodium appetite or cause pica in rats. Significantly inhibits NPY-induced feeding but not through blockade of Y5 receptors.
技术数据 for S 25585
| 分子量 | 528.5 |
| 公式 | C22H23F3N4O6S |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 263849-50-9 |
| PubChem ID | 10029880 |
| InChI Key | BRMJFKLHWFZWOQ-KOMQPUFPSA-N |
| Smiles | O=S(NC[C@H]1CC[C@H]([C@@](NNC(C3=CC=CC=C3)=O)=O)CC1)(C2=CC=C(C(F)(F)F)C=C2[N+]([O-])=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for S 25585
参考文献 for S 25585
参考文献是支持产品生物活性的出版物。
Beauverger et al (2005) Functional characterization of human neuropeptide Y receptor subtype 5 specific antagonists using a luciferase reporter gene assay. Cell.Signal. 17 489 PMID: 15601626
Della-Zuana et al (2004) A potent and selective NPY Y5 antagonist reduces food intake but not through blockade of the NPY Y5 receptor. Int.J.Obes. 28 628
Kamiji and Inui (2007) Neuropeptide Y receptor selective ligands in the treatment of obesity. 28 664
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关键词: S 25585, S 25585 supplier, Potent, selective, NPY, Y5, antagonists, neuropeptide, Receptors, S25585, neuropeptides, 3432, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.