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(S)-(+)-Dimethindene maleate

Cat. No. 1425 6 篇引用文献 2 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective M2 antagonist
化学名： N,N-Dimethyl-3-[(1S)-1-(2-pyridinyl)ethyl]-1H-indene-2-ethanamine maleate
纯度： ≥99% (HPLC)
说明书
引用文献 (6)
评论 (2)
实验方案 (1)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for (S)-(+)-Dimethindene maleate

(S)-(+)-Dimethindene maleate is an enantiomer that is a subtype-selective M2 muscarinic receptor antagonist (pKi values are 7.08, 7.78, 6.70 and 7.00 for M1, M2, M3 and M4 receptors respectively). Also H1 histamine receptor antagonist (pKi = 7.48). Allows formation of extended pluripotent stem (EPS) cells in combination with CHIR 99021 (Cat.No. 4423), minocycline hydrochloride (Cat.No. 3268) and human leukemia inhibitory factor.

For more information about how Dimethindene maleate may be used, see our protocol: Generation and Propagation of EPS cells (LCDM Cocktail).

技术数据 for (S)-(+)-Dimethindene maleate

分子量 408.5
公式 C20H24N2.C4H4O4
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 136152-65-3
PubChem ID 56972160
InChI Key SWECWXGUJQLXJF-HFNHQGOYSA-N
Smiles C[C@H](C3=NC=CC=C3)C2=C(CCN(C)C)CC1=CC=CC=C12.OC(=O)\C=C/C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (S)-(+)-Dimethindene maleate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 29.24 100 温和加热

制备储备液 for (S)-(+)-Dimethindene maleate

以下数据基于产品分子量 408.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.45 mL 12.24 mL 24.48 mL
5 mM 0.49 mL 2.45 mL 4.9 mL
10 mM 0.24 mL 1.22 mL 2.45 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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产品说明书 for (S)-(+)-Dimethindene maleate

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for (S)-(+)-Dimethindene maleate

参考文献是支持产品生物活性的出版物。

Lambrecht et al (1999) Neuronal soma-dendritic and prejunctional M1-M4 receptors in gastrointestinal and genitourinary smooth muscle. Life Sci. 64 403 PMID: 10069503

Pfaff et al (1995) The (S)-(+)-enantiomer of dimethindene: a novel M2-selective muscarinic receptor antagonist. Eur.J.Pharmacol. 286 229 PMID: 8608784

Yang et al (2017) Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency. Cell. 169 243 PMID: 28388409

If you know of a relevant reference for (S)-(+)-Dimethindene maleate, please let us know.

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关键词: (S)-(+)-Dimethindene maleate, (S)-(+)-Dimethindene maleate supplier, H1, antagonists, M2, muscarinic, Receptors, Histamine, Acetylcholine, ACh, histaminergic, Stem, Cell, Reprogramming, 1425, Tocris Bioscience

6 篇 (S)-(+)-Dimethindene maleate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (S)-(+)-Dimethindene maleate 的部分引用包括：

Li et al (2018) Rapid generation of gene-targeted EPS-derived mouse models through tetraploid complementation. Protein Cell PMID: 29948855

Du et al (2019) Efficient derivation of extended pluripotent stem cells from NOD-scid Il2rg-/- mice. Protein Cell 10 31 PMID: 29948854

Xu et al (2019) Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system. Stem Cell Res Ther 10 193 PMID: 31248457

Yang et al (2017) Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency. Cell 169 243 PMID: 28388409

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ESC culture.
By Anonymous on 11/23/2021
分析类型： In Vitro
种属： Mouse
细胞系/组织： ESC

In vitro cell culture addition. The image shows the morphology of ESC colonies after conversion by using the treatment condition. This condition supported the conversion and long-term maintenance of dome-shaped ESCs from primed ESCs.

review image
Generation of EPS-blastoids.
By Anonymous on 02/27/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： EPS

2uM

PMID: 31626770
review image

(S)-(+)-Dimethindene maleate 实验方案

以下实验方案包含使用 (S)-(+)-Dimethindene maleate（目录编号 1425）的更多信息。

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