(S)-Duloxetine hydrochloride

Cat. No. 4798 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent 5-HT and NA reuptake inhibitor (SNRI); also blocks dopamine reuptake

化学名： (+)-(S)-N-Methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine hydrochloride

纯度： ≥99% (HPLC)

引用文献 (4)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for (S)-Duloxetine hydrochloride

(S)-Duloxetine hydrochloride is a high affinity, competitive 5-HT and noradrenaline (NA) re-uptake inhibitor (K_i values are 8.5 and 45 nM for 5-HT and NA reuptake respectively in cortical synaptosomes; IC₅₀ values are 28 and 46 nM for 5-HT and NA reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (K_i = 300 nM in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.

化合物库 for (S)-Duloxetine hydrochloride

(S)-Duloxetine hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for (S)-Duloxetine hydrochloride

分子量	333.88
公式	C₁₈H₁₉NOS.HCl
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	136434-34-9
PubChem ID	60834
InChI Key	BFFSMCNJSOPUAY-LMOVPXPDSA-N
Smiles	CNCC[C@@H](C3=CC=CS3)OC2=CC=CC1=CC=CC=C12.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for (S)-Duloxetine hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	3.34	10 温和加热
	DMSO	33.39	100

制备储备液 for (S)-Duloxetine hydrochloride

以下数据基于产品分子量 333.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3 mL	14.98 mL	29.95 mL
5 mM	0.6 mL	3 mL	5.99 mL
10 mM	0.3 mL	1.5 mL	3 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

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产品说明书 for (S)-Duloxetine hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for (S)-Duloxetine hydrochloride

参考文献是支持产品生物活性的出版物。

Wong et al (1988) LY227942, an inhibitor of serotonin and NE uptake: biochemical pharmacology of a potential antidepressant drug. Life Sci. 43 2049 PMID: 2850421

Kasamo et al (1996) Blockade of the serotonin and NE uptake processes by duloxetine: in vitro and in vivo studies in the rat brain. J.Pharmacol.Exp.Ther. 277 278 PMID: 8613930

If you know of a relevant reference for (S)-Duloxetine hydrochloride, please let us know.

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关键词: (S)-Duloxetine hydrochloride, (S)-Duloxetine hydrochloride supplier, SNRI, 5-HT, NE, norepinephrine, noradrenaline, reuptake, inhibitors, inhibits, potent, high, affinity, antidepressants, anxiolytics, orally, available, anxiety, depression, Transporters, Adrenergic, Dopamine, 4798, Tocris Bioscience

4 篇 (S)-Duloxetine hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 (S)-Duloxetine hydrochloride 的部分引用包括：

Skelly and Weiner (2014) Chronic treatment with pra. or dulox. lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use. Brain Behav 4 468 PMID: 25161814

Melitta et al (2022) Mitochondrial and Neuronal Dysfunctions in L1 Mutant Mice. Int J Mol Sci 23 PMID: 35457156

Gordon F et al (2019) Effect of monoamine reuptake inhibition and α1 blockade on respiratory arrest and death following electroshock-induced seizures in mice. Epilepsia 60 495-507 PMID: 30723893

Henry A et al (2020) Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell 183 1986-2002.e26 PMID: 33333022

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