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Submit ReviewSaclofen
说明： Selective GABAB antagonist
化学名： (RS)-3-Amino-2-(4-chlorophenyl)propylsulfonic acid
纯度： ≥99% (HPLC)
生物活性 for Saclofen
Saclofen is a selective antagonist at GABAB receptors.
技术数据 for Saclofen
| 分子量 | 249.72 |
| 公式 | C9H12ClNO3S |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 125464-42-8 |
| PubChem ID | 122150 |
| InChI Key | JYLNVJYYQQXNEK-UHFFFAOYSA-N |
| Smiles | NCC(CS(O)(=O)=O)C1=CC=C(Cl)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Saclofen
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 2.5 | 10 |
制备储备液 for Saclofen
以下数据基于产品分子量 249.72。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 40.04 mL | 200.22 mL | 400.45 mL |
| 0.5 mM | 8.01 mL | 40.04 mL | 80.09 mL |
| 1 mM | 4 mL | 20.02 mL | 40.04 mL |
| 5 mM | 0.8 mL | 4 mL | 8.01 mL |
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产品说明书 for Saclofen
参考文献 for Saclofen
参考文献是支持产品生物活性的出版物。
Bowery (1989) GABAB receptors and their significance in mammalian pharmacology. TiPS 10 401 PMID: 2559518
Jane et al (1990) Use of the neonatal rat spinal cord in studies of the GABAB receptor. GABAB receptors in Mammalian Function. 42b
If you know of a relevant reference for Saclofen, please let us know.
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关键词: Saclofen, Saclofen supplier, Selective, GABAB, antagonists, Receptors, 0246, Tocris Bioscience
10 篇 Saclofen 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Saclofen 的部分引用包括：
Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Mol Pain 488 172 PMID: 22801496
Miyazato et al (2008) GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats. J Urol 179 1178 PMID: 18206170
Atasoy et al (2014) A genetically specified connectomics approach applied to long-range feeding regulatory circuits. Nat Neurosci 17 1830 PMID: 25362474
Kramár et al (2009) Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. Cereb Cortex 29 12982 PMID: 19828812
Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. J Neurosci 131 1050 PMID: 11082110
Ohba et al (2005) BDNF locally potentiates GABAergic presynaptic machineries: target-selective circuit inhibition. Proc Natl Acad Sci U S A 15 291 PMID: 15238431
Piet et al (2004) Physiological contribution of the astrocytic environment of neurons to intersynaptic crosstalk. J Neurosci 101 2151 PMID: 14766975
Melyan et al (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci 24 4530 PMID: 15140923
Ying and Goldstein (2005) PropF. suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels. J Neurosci 1 2 PMID: 15813991
Harte-Hargrove et al (2015) Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat. Br J Pharmacol 35 1723 PMID: 25632146
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.