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SAHA-FITC

Cat. No. 7970 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Fluorescent HDAC1/2 probe; suitable for use in TR-FRET and FP assays
化学名： 2-(6-Hydroxy-3-oxo-3H-xanthen-9-yl)-5-(3-(4-(8-(hydroxyamino)-8-oxooctanamido)benzyl)thioureido)benzoic acid
纯度： ≥90% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SAHA-FITC

SAHA-FITC is a fluorescent HDAC1/2 probe for use as a TR-FRET acceptor for CoraFluor labeling and in fluorescence polarization binding assays. Binds non-selectively to HDAC1 and HDAC2 (Kd values are 56 nM and 132 nM respectively; Ki = 1.5 nM).

Optical Data for SAHA-FITC

SAHA-FITC Dye Spectra
Emission Color Green
λabs 495 nm
λem 525 nm

Plan Your Experiments

Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.

Spectral Viewer

Spectral Viewer

技术数据 for SAHA-FITC

分子量 682.75
公式 C36H34N4O8S
储存 Store at -20°C
纯度 ≥90% (HPLC)
CAS Number 1160823-10-8
PubChem ID 44123666
InChI Key GQKWRDWQZXNRAB-UHFFFAOYSA-N
Smiles OC(C=C1OC2=C3)=CC=C1C(C4=CC=C(NC(NCC5=CC=C(NC(CCCCCCC(NO)=O)=O)C=C5)=S)C=C4C(O)=O)=C2C=CC3=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SAHA-FITC

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 6.83 10

制备储备液 for SAHA-FITC

以下数据基于产品分子量 682.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 14.65 mL 73.23 mL 146.47 mL
0.5 mM 2.93 mL 14.65 mL 29.29 mL
1 mM 1.46 mL 7.32 mL 14.65 mL
5 mM 0.29 mL 1.46 mL 2.93 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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参考文献 for SAHA-FITC

参考文献是支持产品生物活性的出版物。

Kral et al (2014) Divergent kinetics differentiate the mechanism of action of two HDAC inhibitors. Biochemistry 53 725 PMID: 24450491

Payne and Mazitschek (2022) Resolving the deceptive isoform and complex selectivity of HDAC1/2 inhibitors. Cell Chem.Biol. 29 1140 PMID: 35298895

If you know of a relevant reference for SAHA-FITC, please let us know.

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关键词: SAHA-FITC, SAHA-FITC supplier, SAHAFITC, SAHA, FITC, TR-FRET, TRFRET, fluorescence, HDAC, histone, deacetylase, fluorescein, isothiocyanate, and, FP, Assay, Reagents, Class, I, HDACs, 7970, Tocris Bioscience

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