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Submit ReviewSAHA
说明： Class I and II HDAC inhibitor
别名： Vorinostat
化学名： N-Hydroxy-N'-phenyloctanediamide
纯度： ≥98% (HPLC)
生物活性 for SAHA
SAHA inhibits Class I and II histone deacetylases (HDACs); induces accumulation of acetylated histones H2A, H2B, H3 and H4 in transformed cultured cells. Suppresses cell growth in a range of cancer cell lines; induces apoptosis in cutaneous T cell lymphoma cells in vitro. Activates autophagy. SAHA increases efficiency of transcription factor-induced reprogramming of mouse embryonic fibroblasts (MEF) to induced pluripotent stem cells (iPSC). Enhances adeno-associated virus transduction of HeLa cells. Also induces activation and replication of latent HIV in vitro.
化合物库 for SAHA
SAHA is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library, Tocriscreen Epigenetics Library, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for SAHA
| 分子量 | 264.32 |
| 公式 | C14H20N2O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 149647-78-9 |
| PubChem ID | 5311 |
| InChI Key | WAEXFXRVDQXREF-UHFFFAOYSA-N |
| Smiles | O=C(CCCCCCC(NO)=O)NC1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SAHA
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 26.43 | 100 |
制备储备液 for SAHA
以下数据基于产品分子量 264.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.78 mL | 18.92 mL | 37.83 mL |
| 5 mM | 0.76 mL | 3.78 mL | 7.57 mL |
| 10 mM | 0.38 mL | 1.89 mL | 3.78 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
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产品说明书 for SAHA
参考文献 for SAHA
参考文献是支持产品生物活性的出版物。
Butler et al (2000) Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo. Cancer Res. 60 5165 PMID: 11016644
Leoni et al (2002) The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines. Proc.Natl.Acad.Sci.U.S.A 99 2995 PMID: 11867742
Marks and Breslow (2007) Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat.Biotechnol. 25 84 PMID: 17211407
Huangfu et al (2008) Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat.Biotechnol. 26 795 PMID: 18568017
Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. 16 487 PMID: 28529316
Nicolson et al (2016) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens. J.Virol. 90 7019 PMID: 27147738
Narasipura et al (2014) Epigenetic regulation of HIV-1 latency in astrocytes. J.Virol. 88 3031 PMID: 24352441
If you know of a relevant reference for SAHA, please let us know.
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关键词: SAHA, SAHA supplier, histone, deacetylases, HDACs, inhibits, inhibitors, Class, I, II, vorinostat, anticancer, antiproliferatives, epigenetics, proapoptotic, viral, transduction, enhancer, enhances, stem, cell, reporgramming, Vorinostat, Autophagy, Non-selective, Non-Selective, Viral, Transduction, Enhancers, Stem, Cell, Reprogramming, 4652, Tocris Bioscience
8 篇 SAHA 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SAHA 的部分引用包括：
Steven L et al (2022) INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury. Nat Commun 13 6037 PMID: 36229429
Jacques et al (2022) Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes. Elife 11 PMID: 36111670
Nianli et al (2019) Compounds targeting class II histone deacetylases do not cause panHDACI-associated impairment of megakaryocyte differentiation. Exp Hematol 72 36-46 PMID: 30611870
Bhattacharya et al (2017) RAD51 interconnects between DNA replication, DNA repair and immunity. Nucleic Acids Res 45 4590 PMID: 28334891
Asgerally T et al (2020) ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation. Cell Rep 33 108366 PMID: 33176148
Gergely et al (2020) Celecoxib Prevents Doxorubicin-Induced Multidrug Resistance in Canine and Mouse Lymphoma Cell Lines. Cancers (Basel) 12 PMID: 32365663
Sarenac et al (2016) Single-cell analysis reveals IGF-1 potentiation of inhibition of the TGF-β/Smad pathway of fibrosis in humankeratocytes in vitro Scientific Reports 6 34373 PMID: 27687492
Ng-Blichfeldt et al (2018) Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation. EBioMedicine 36 461 PMID: 30236449
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SAHA 的评论
平均评分: 5 (Based on 1 Review.)
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Excellent histone deacetylase inhibitor.
By
Luiz Alexandre Magno on 11/25/2021
分析类型： In Vitro
种属： Rat
细胞系/组织： PC12
Our lab uses this drug to monitor transcriptional activity of genes that depend on class I, II and IV of histone deacetylase. In the experiment shown in the figure, we have treated PC12 cells with 3 different concentrations of SAHA for 3h. We found increased transcriptional activity of PI3K gene upon SAHA treatment in a dose-dependent manner.
SAHA can be easily resuspended in DMSO. Make a stock solution with a concentration that will not exceed 0.01% of DMSO in the cell culture to avoid toxicity.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Rheumatoid Arthritis Poster
Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.