主页 / 药理学 / Ion Channels / Calcium Channels / Voltage-gated Calcium Channels (CaV) / CaV3.x Channels (T-type) / CaV3.x Channel (T-type) Activators / SAK 3

SAK 3

Cat. No. 6239 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent CaV3.1 and 3.3 activator; orally bioavailable
化学名： Ethyl 8'-methyl-2',4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1,3'-imidazo[1,2-a]pyridine]-3-carboxylate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SAK 3

SAK 3 is a potent CaV3.1 and CaV3.3 activator. Enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01 - 10 M in neuro2A cells in vitro. Elevates ACh levels in hippocampus. Rescues impaired memory-related behaviors, promotes adult neurogenesis and displays antidepressant-like effects in OBX mice. Orally bioavailable.

化合物库 for SAK 3

SAK 3 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SAK 3

分子量 369.41
公式 C20H23N3O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1256269-87-0
PubChem ID 71655974
InChI Key WZHBYTVHUFURPY-UHFFFAOYSA-N
Smiles O=C(C1=C(C2(N3C=CC=C(C3=NC2=O)C)CC1=O)N4CCCCC4)OCC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SAK 3

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.94 100
1eq. HCl 36.94 100

制备储备液 for SAK 3

以下数据基于产品分子量 369.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.71 mL 13.54 mL 27.07 mL
5 mM 0.54 mL 2.71 mL 5.41 mL
10 mM 0.27 mL 1.35 mL 2.71 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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参考文献 for SAK 3

参考文献是支持产品生物活性的出版物。

Yabuki et al (2017) Pharmacological properties of SAK3, a novel T-type voltage-gated Ca2+ channel enhancer. Neuropharmacology 117 1 PMID: 28093211

Xu et al (2018) T-type calcium channel enhancer SAK3 produces anti-depressant-like effects by promoting adult hippocampal neurogenesis in olfactory bulbectomized mice. J.Pharmacol.Sci. 137 333 PMID: 30196018

If you know of a relevant reference for SAK 3, please let us know.

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关键词: SAK 3, SAK 3 supplier, SAK3, voltage-gated, Ca2+, channels, T-VGCC, memory, orally, bioavailable, CaV3.1, Ca3.3, activators, activates, Cav3.x, Channels, 6239, Tocris Bioscience

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