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Submit ReviewSalirasib
说明： Ras inhibitor; also induces autophagy
化学名： 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic acid
纯度： ≥98% (HPLC)
生物活性 for Salirasib
Salirasib is an inhibitor of active Ras proteins. Displaces active Ras from the plasma membrane; impairs downstream signaling and inhibits proliferation of endometrial carcinoma cells. Also facilitates Ras degradation. Shown to induce autophagy in several human cancer cell lines.
技术数据 for Salirasib
| 分子量 | 358.54 |
| 公式 | C22H30O2S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 162520-00-5 |
| PubChem ID | 5469318 |
| InChI Key | WUILNKCFCLNXOK-CFBAGHHKSA-N |
| Smiles | C\C(CC/C=C(C)/CC/C=C(C)/C)=C/CSC1=CC=CC=C1C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Salirasib
参考文献 for Salirasib
参考文献是支持产品生物活性的出版物。
Schmukler et al (2013) Ras inhibition enhances autophagy, which partially protects cells from death. Oncotarget 4 142 PMID: 23370967
Faigenbaum et al (2013) Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib. Oncotarget 4 316 PMID: 23530112
Haklai et al (1998) Dislodgement and accelerated degradation of Ras. Biochemistry 37 1306 PMID: 9477957
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关键词: Salirasib, Salirasib supplier, Ras, inhibitors, inhibits, induces, autophagy, Autophagy, GTPases, 4989, Tocris Bioscience
2 篇 Salirasib 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Salirasib 的部分引用包括：
Li et al (2018) Is Ras a potential target in treatment against cutaneous squamous cell carcinoma?. J Cancer 9 3373 PMID: 30271499
Lee et al (2015) A systems-biological study on the identification of safe and effective molecular targets for the reduction of ultraviolet B-induced skin pigmentation. J Virol 5 10305 PMID: 25980672
Salirasib 的评论
平均评分: 5 (Based on 1 Review.)
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Salirasib blocks LPA-mediated COX-2 expression.
By
Anonymous on 12/13/2018
分析类型： In Vitro
种属： Human
细胞系/组织： Osteosarcoma
Human osteosarcoma cells were incubated with 20 μM Salirasib for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. Salirasib abolished LPA-induced COX-2 expression.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cancer Metabolism Research Product Guide
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Glycolysis
- Tricarboxylic Acid Cycle
- Lipidogenesis
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance
RAS Oncoproteins Scientific Review
Written by Kirsten L. Bryant, Adrienne D. Cox and Channing J. Der, this review provides a comprehensive overview of RAS protein function and RAS mutations in cancer. Key signaling pathways are highlighted and therapeutic vulnerabilities are explored. This review also includes a detailed section on RAS drug discovery and targeting synthetic lethal interactors of mutant RAS. Compounds available from Tocris are listed.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Epigenetics in Cancer Poster
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Pathways for Salirasib
Akt Signaling Pathway
The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.