Ras GTPase Inhibitors
| Cat. No. | Product Name / Activity |
|---|---|
| 7713 | AMG 510 |
| Potent and selective KRASG12C inhibitor | |
| 6791 | BC-LI-0186 |
| Leucyl-tRNA synthase (TRS)/Ras-related GTP-binding protein D (RagD) interaction inhibitor | |
| 6407 | Fendiline Hydrochloride |
| Inhibits KRas localization to the plasma membrane; also L-type calcium channel blocker | |
| 5607 | GNF 7 |
| Ras signaling inhibitor; inhibits Ack1 and GCK | |
| 6429 | ML 210 |
| Selectively kills mutant HRAS-expressing cells; glutathione peroxidase inhibitor; induces ferroptosis | |
| 7488 | MRTX 849 |
| Mutation-selective inhibitor of KRASG12C | |
| 6111 | Zoledronic Acid |
| Ras signaling inhibitor; also potent farnesyl diphosphate (FPP) synthase inhibitor |
Cancer Metabolism Product Guide
Our product guide reviews some of the main areas in cancer metabolism research and highlights products that can be used to explore metabolic pathways.
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Our review provides a thorough overview of RAS protein function and RAS mutations in cancer. Key signaling pathways are highlighted and therapeutics vulnerabilities are explored with a detailed section on RAS drug discovery.
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Our Cell Cycle & DNA Damage Repair poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
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Taken from the Cancer Product Guide Edition 3
Our Epigenetics in Cancer poster summarizes the main epigenetic targets in cancer, and highlights chemical compounds for the inhibition of these targets.
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