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Submit ReviewSalvinorin A
Discontinued Product
2134 has been discontinued.
说明： Highly potent and selective κ agonist
别名： Divinorin A
化学名： (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
纯度： ≥98% (HPLC)
生物活性 for Salvinorin A
Salvinorin A is a potent naturally occuring non-nitrogenous κ-opioid selective agonist that displays high affinity at both native (Ki = 4.3 nM) and cloned (Ki = 16 nM) κ-opioid receptors. Also exhibits allosteric modulation of μ-opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties..
External Portal Information for Salvinorin A
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of Salvinorin A is reviewed on the chemical probes website.
技术数据 for Salvinorin A
| 分子量 | 432.47 |
| 公式 | C23H28O8 |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 83729-01-5 |
| PubChem ID | 128563 |
| InChI Key | OBSYBRPAKCASQB-AGQYDFLVSA-N |
| Smiles | O=C3[C@]2([H])CC[C@@]([C@]([H])1[C@](C)2C[C@@H]([C@]4=COC=C4)O3)(C)[C@H]([C@@](OC)=O)C[C@H](OC(C)=O)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Salvinorin A
参考文献 for Salvinorin A
参考文献是支持产品生物活性的出版物。
Rothman et al (2007) Salvinorin A: allosteric interactions at the μ-opioid receptor. J.Pharmacol.Exp.Ther. 320 801 PMID: 17060492
Roth et al (2002) Salvinorin A: a potent naturally occuring nonnitrogenous κ opioid selective agonist. Proc.Natl.Acad.Sci.USA 99 11934
Scheffler and Roth (2003) Salvinorin A: the 'magic mint' hallucinogen finds a molecular target in the kappa opioid receptor. TiPS. 24 107
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关键词: Salvinorin A, Salvinorin A supplier, potent, selective, κ-opioid, kappa-opioid, agonists, KOP, Receptors, OP2, SalvinorinA, DivinorinA, Divinorin, A, Kappa, Opioid, 2134, Tocris Bioscience
3 篇 Salvinorin A 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Salvinorin A 的部分引用包括：
Braida et al (2009) Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents. Br J Pharmacol 157 844 PMID: 19422370
Coffeen et al (2018) Salvinorin A reduces neuropathic nociception in the insular cortex of the rat. Eur.J.Pain. 22 311 PMID: 28975684
Mundra et al (2012) Naltrindole inhibits human multiple myeloma cell proliferation in vitro and in a murine xenograft model in vivo. J Pharmacol Exp Ther 342 273 PMID: 22537770
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