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Santacruzamate A

Cat. No. 7191 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Highly potent and selective HDAC2 inhibitor
化学名： Ethyl N-[4-oxo-4-[(2-phenylethyl)amino]butyl]carbamate
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (4)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Santacruzamate A

Santacruzamate A is a highly potent and selective histone deactylase 2 (HDAC2) inhibitor (IC50 = 112 - 119 pM). Also inhibits HDAC6 in nanomolar range (IC50 = 433 nM). Displays >3500 fold selectivity for HDAC2 over HDAC6, and >8500-fold selectivity over HDAC4 (IC50 >1 μM for HDAC4). Inhibits growth of HuT-78 cutaneous T-cell lymphoma cell line. Identified as targeting human host proteins that interact with SARS-CoV-2.

化合物库 for Santacruzamate A

Santacruzamate A is also offered as part of the Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Santacruzamate A

分子量 278.35
公式 C15H22N2O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1477949-42-0
PubChem ID 72946782
InChI Key HTOYBIILVCHURC-UHFFFAOYSA-N
Smiles CCOC(=O)NCCCC(=O)NCCC1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Santacruzamate A

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 27.84 100

制备储备液 for Santacruzamate A

以下数据基于产品分子量 278.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.59 mL 17.96 mL 35.93 mL
5 mM 0.72 mL 3.59 mL 7.19 mL
10 mM 0.36 mL 1.8 mL 3.59 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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产品说明书 for Santacruzamate A

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Santacruzamate A

参考文献是支持产品生物活性的出版物。

Pavlik et al (2013) Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J.Nat.Prod. 76 2026 PMID: 24164245

Gordon et al (2020) A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature. 583 459 PMID: 32353859

If you know of a relevant reference for Santacruzamate A, please let us know.

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关键词: Santacruzamate A, Santacruzamate A supplier, CAY10683, CAY, 10683, histone, deacetylase, 2, HDAC2, inhibitors, inhibits, highly, potent, selective, Class, I, HDACs, COVID-19, Coronavirus, 7191, Tocris Bioscience

1 篇 Santacruzamate A 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Santacruzamate A 的部分引用包括：

Steven L et al (2022) INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury. Nat Commun 13 6037 PMID: 36229429

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Epigenetics in Cancer Poster

Epigenetics in Cancer Poster

This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.