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Submit Review[Sar9,Met(O2)11]-Substance P
说明： Potent and selective NK1 agonist
纯度： ≥95% (HPLC)
生物活性 for [Sar9,Met(O2)11]-Substance P
[Sar9,Met(O2)11]-Substance P is a potent selective NK1 tachykinin receptor agonist.
技术数据 for [Sar9,Met(O2)11]-Substance P
| 分子量 | 1393.68 |
| 公式 | C64H100N18O15S |
| 序列 |
RPKPQQFFXLM (Modifications: X = Sar, Met-11 = Met(O2) & C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 110880-55-2 |
| PubChem ID | 163829 |
| InChI Key | OUPXSLGGCPUZJJ-SARDKLJWSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N(C)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCS(C)(=O)=O)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for [Sar9,Met(O2)11]-Substance P
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for [Sar9,Met(O2)11]-Substance P
参考文献 for [Sar9,Met(O2)11]-Substance P
参考文献是支持产品生物活性的出版物。
Cellier et al (1999) Characterisation of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br.J.Pharmacol. 127 717 PMID: 10401563
King et al (1997) Profile of neuronal excitation following selective activation of the neurokinin-1 receptor in rat deep dorsal horn in vitro. Brain Res. 767 55 PMID: 9365015
Li and Zhao (1998) Small sensory neurons in the rat dorsal root ganglia express functional NK-1 tachykinin receptor. Eur.J.Neurosci. 10 1292 PMID: 9749783
Tousignant et al (1990) 125I-BH[Sar9,Met(O2)11]-SP, a new selective ligand for the NK-1 receptor in the central nervous system. Brain Res. 524 263 PMID: 1705465
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关键词: [Sar9,Met(O2)11]-Substance P, [Sar9,Met(O2)11]-Substance P supplier, Potent, selective, NK1, agonists, Tachykinin, Receptors, Neurokinin, [Sar9Met(O2)11]-SubstanceP, Receptor, 1178, Tocris Bioscience
2 篇 [Sar9,Met(O2)11]-Substance P 的引用文献
引用文献是使用了 Tocris 产品的出版物。 [Sar9,Met(O2)11]-Substance P 的部分引用包括：
Khasabov et al (2017) Hyperalgesia and sensitization of dorsal horn neurons following activation of NK-1 receptors in the rostral ventromedial medulla. J Neurophysiol 118 2727 PMID: 28794197
Pal et al (2013) Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. J Biol Chem 288 3265 PMID: 23235155
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