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Submit ReviewSB 200646 hydrochloride
说明： 5-HT2C/2B antagonist
化学名： N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea
纯度： ≥98% (HPLC)
生物活性 for SB 200646 hydrochloride
SB 200646 hydrochloride is a 5-HT2C/2B receptor antagonist, selective over 5-HT1A. Affinities are 7.4 (pA2), 6.9 (pKi) and 5.2 (pKi) for 5-HT2B, 2C and 2A respectively. Orally active in vivo.
许可信息
Sold under license
技术数据 for SB 200646 hydrochloride
| 分子量 | 302.76 |
| 公式 | C15H14N4O.HCl |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 143797-62-0 |
| PubChem ID | 5311422 |
| InChI Key | IGRYPUQJEDJLHC-UHFFFAOYSA-N |
| Smiles | Cl.CN1C=CC2=CC(NC(=O)NC3=CN=CC=C3)=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SB 200646 hydrochloride
参考文献 for SB 200646 hydrochloride
参考文献是支持产品生物活性的出版物。
Forbes et al (1993) N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT1C receptor antagonist. J.Med.Chem. 36 1104 PMID: 8478907
Kennett et al (1994) In vivo properties of SB 200646A, a 5-HT2C/2B recepor antagonist. Br.J.Pharmacol. 111 797 PMID: 7912626
Kennett et al (1995) Effect of SB 200646A, a 5-HT2C/5-HT2B receptor antagonist, in two conflict models of anxiety. Psychopharmacology (Berl.) 118 178 PMID: 7617805
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关键词: SB 200646 hydrochloride, SB 200646 hydrochloride supplier, 5-HT2C/2B, antagonists, Serotonin, 5-HT2B, Receptors, SB200646, hydrochloride, 5-HT2C, 1371, Tocris Bioscience
1 篇 SB 200646 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SB 200646 hydrochloride 的部分引用包括：
Xiao et al (2008) Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling. Am J Physiol Endocrinol Metab 4 12 PMID: 18416824
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.