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Submit ReviewSB 203186 hydrochloride
说明： 5-HT4 antagonist
化学名： 1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride
纯度： ≥99% (HPLC)
生物活性 for SB 203186 hydrochloride
SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist with high affinity for human atrial 5-HT4 receptors.
许可信息
Sold with the permission of GlaxoSmithKline
技术数据 for SB 203186 hydrochloride
| 分子量 | 308.81 |
| 公式 | C16H20N2O2.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 207572-69-8 |
| PubChem ID | 9926639 |
| InChI Key | LYMBEMCUJNDSBZ-UHFFFAOYSA-N |
| Smiles | Cl.O=C(OCCN1CCCCC1)C1=CNC2=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SB 203186 hydrochloride
参考文献 for SB 203186 hydrochloride
参考文献是支持产品生物活性的出版物。
McLean and Coupar (1995) 5-HT4 receptor antagonist affinities of SB207710, SB205008 and SB 203186 in the human colon, rat oesophagus and guinea-pig ileum peristaltic reflex. Naunyn Schmiedebergs Arch.Pharmacol. 352 132 PMID: 747435
Midhurst and Kaumann et al (1993) Characterisation of 5-HT4 receptor mediating tachycardia in piglet isolated right atrium. Br.J.Pharmacol. 110 1023 PMID: 8298790
Parker et al (1995) Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186. Naunyn Schmiedebergs Arch.Pharmacol. 353 28 PMID: 8750913
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.