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Submit ReviewSB 204070
说明： Potent and selective 5-HT4 antagonist
化学名： 8-Amino-7-chloro-2,3-dihydro-1,4-benzodioxan-5-carboxylic acid, 1'-butyl-4'-piperidinylmethyl ester
纯度： ≥98% (HPLC)
生物活性 for SB 204070
SB 204070 is a potent and selective 5-HT4 receptor antagonist (pIC50 = 10.1). Displays >5000-fold selectivity for 5-HT4 over 5-HT1A, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2C, and 5-HT3 receptors. Exhibits anxiolytic activity upon systemic administration in vivo.
许可信息
Sold for research purposes under agreement from GlaxoSmithKline.
技术数据 for SB 204070
| 分子量 | 419.34 |
| 公式 | C19H27ClN2O4.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 148688-01-1 |
| PubChem ID | 121880 |
| InChI Key | YEQGKAOSYSXEPU-UHFFFAOYSA-N |
| Smiles | ClC1=C(N)C(OCCO2)=C2C(C(OCC3CCN(CCCC)CC3)=O)=C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SB 204070
参考文献 for SB 204070
参考文献是支持产品生物活性的出版物。
Bingham et al (1995) Antagonism by SB 204070 of 5-HT-evoked contractions in the dog stomach: an in-vivo model of 5-HT4 receptor function. J.Pharm.Pharmacol. 47 219 PMID: 7602484
Gaster et al (1993) (1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT4 antagonist derived from metoclopr. J.Med.Chem. 36 4121 PMID: 8258837
Prins et al (2000) An improved in vitro bioassay for the study of 5-HT4 receptors in the human isolated large intestine circular muscle. Br.J.Pharmacol. 129 1601 PMID: 10780964
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关键词: SB 204070, SB 204070 supplier, Serotonin, serotonergics, selective, 5-HT4, receptors, antagonists, anxiolytics, SB204070, Receptors, 1373, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.