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SB 222200

Cat. No. 1393 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent, selective non-peptide NK3 antagonist. Brain penetrant
化学名： 3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SB 222200

SB 222200 is a potent and selective non-peptide NK3 receptor antagonist (Ki values are 4.4, > 100,000 and 250 nM for human NK3, NK1 and NK2 receptors respectively). Antihypertensive in vivo. Brain penetrant.

许可信息

Sold under license

化合物库 for SB 222200

SB 222200 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SB 222200

分子量 380.48
公式 C26H24N2O
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 174635-69-9
PubChem ID 6604009
InChI Key MQNYRKWJSMQECI-QFIPXVFZSA-N
Smiles O=C(C2=C(C)C(C4=CC=CC=C4)=NC3=CC=CC=C23)N[C@@H](CC)C1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 222200

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 100
ethanol 100

制备储备液 for SB 222200

以下数据基于产品分子量 380.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.63 mL 13.14 mL 26.28 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
10 mM 0.26 mL 1.31 mL 2.63 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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产品说明书 for SB 222200

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for SB 222200

参考文献是支持产品生物活性的出版物。

Medhurst et al (1997) In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists. Br.J.Pharmacol. 122 469 PMID: 9351503

Sarau et al (2000) Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist. J.Pharmacol.Exp.Ther. 295 373 PMID: 10992004

De Brito Gariepy and Couture (2010) Blockade of tachykinin NK3 receptor reverses hypertension through a DArgic mechanism in the ventral tegmental area of spontaneously hypertensive rats. Br.J.Pharmacol. 161 1868 PMID: 20804497

If you know of a relevant reference for SB 222200, please let us know.

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关键词: SB 222200, SB 222200 supplier, Potent, selective, non-peptide, NK3, antagonists, Brain, penetrant, Tachykinin, Receptors, Neurokinin, SB222200, Receptor, 1393, Tocris Bioscience

2 篇 SB 222200 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SB 222200 的部分引用包括：

Stein et al (2009) Eosinophils utilize multiple chemokine receptors for chemotaxis to the parasitic nematode Strongyloides stercoralis. J Innate Immun 1 618 PMID: 20375616

Gallopin et al (2006) Cortical sources of CRF, NKB, and CCK and their effects on pyramidal cells in the neocortex. Mol Cancer 16 1440 PMID: 16339088

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.