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Submit ReviewSB 297006
说明： Potent and selective CCR3 antagonist
化学名： N-Benzoyl-4-nitroaniline ethyl ester
纯度： ≥99% (HPLC)
生物活性 for SB 297006
SB 297006 is a potent and selective CCR3 antagonist (IC50 = 39 nM). Displays 250-fold selectivity for CCR3 over other chemokine receptors, including CXCR1, CXCR2, CCR1 and CCR7 (IC50 >27 μM). Inhibits calcium mobilization induced by MCP-4, eotaxin-2 and eotaxin in RBL-2H3 cells transfected with CCR3 (IC50 values are 80, 90 and 210 nM respectively).
化合物库 for SB 297006
SB 297006 is also offered as part of the Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。
技术数据 for SB 297006
| 分子量 | 342.35 |
| 公式 | C18H18N2O5 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 58816-69-6 |
| PubChem ID | 9840971 |
| InChI Key | BEZXGSZPWXRHIN-INIZCTEOSA-N |
| Smiles | O=C(C2=CC=CC=C2)N[C@H](C(OCC)=O)CC1=CC=C([N+]([O-])=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SB 297006
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 34.23 | 100 | |
| ethanol | 6.85 | 20 |
制备储备液 for SB 297006
以下数据基于产品分子量 342.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.92 mL | 14.6 mL | 29.21 mL |
| 5 mM | 0.58 mL | 2.92 mL | 5.84 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.92 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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产品说明书 for SB 297006
参考文献 for SB 297006
参考文献是支持产品生物活性的出版物。
Yoshimoto and Hansch (1976) Quantitative structure-activity relationships of D- and L-N-actyl-alpha-aminoamide ligands binding to chymotrypsin. On the problem of combined treatment of stereoisomers. J.Org.Chem. 41 2269 PMID: 932854
White et al (2000) Identification of a potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J.Biol.Chem. 275 36626 PMID: 10969084
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关键词: SB 297006, SB 297006 supplier, SB297006, ccr3, chemokines, receptors, antagonists, selective, potent, Rantes, Chemokine, CC, Receptors, 4213, Tocris Bioscience
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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