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SB 328437

Cat. No. 3650 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective CCR3 antagonist
化学名： N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalanine methyl ester
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SB 328437

SB 328437 is a potent and selective CCR3 antagonist (IC50 = 4 nM). Displays > 2500-fold selectivity over C5aR, LTD4, CCR7, CXCR1 and CXCR2 receptors. Inhibits eotaxin-, eotaxin-2- and MCP-4-induced Ca2+ mobilization (IC50 values are 38, 35 and 20 nM respectively) and inhibits eotaxin-, eotaxin-2- and MCP-4-induced eosinophil chemotaxis with similar potencies.

化合物库 for SB 328437

SB 328437 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SB 328437

分子量 378.38
公式 C21H18N2O5
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 247580-43-4
PubChem ID 10474776
InChI Key VMFGCGRAIBLAFY-IBGZPJMESA-N
Smiles O=C(C2=CC=CC3=C2C=CC=C3)N[C@H](C(OC)=O)CC1=CC=C([N+]([O-])=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 328437

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 37.84 100

制备储备液 for SB 328437

以下数据基于产品分子量 378.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.64 mL 13.21 mL 26.43 mL
5 mM 0.53 mL 2.64 mL 5.29 mL
10 mM 0.26 mL 1.32 mL 2.64 mL
50 mM 0.05 mL 0.26 mL 0.53 mL

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产品说明书 for SB 328437

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for SB 328437

参考文献是支持产品生物活性的出版物。

White et al (2000) Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J.Biol.Chem. 275 36626 PMID: 10969084

Mori et al (2007) Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists. Int.Immunol. 19 913 PMID: 17804691

Abonyo et al (2005) Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation. Am.J.Physiol.Lung Cell.Mol.Physiol. 289 L478 PMID: 15863444

If you know of a relevant reference for SB 328437, please let us know.

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关键词: SB 328437, SB 328437 supplier, SB328437, Potent, selective, CCR3, antagonists, chemokine, receptors, Rantes, Chemokine, CC, Receptors, 3650, Tocris Bioscience

2 篇 SB 328437 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SB 328437 的部分引用包括：

Christoph et al (2012) Graft-versus-host disease reduces regulatory T-cell migration into the tumour tissue. Immunology 137 80-8 PMID: 22681312

Jing et al (2020) Blocking the autocrine regulatory loop of Gankyrin/STAT3/CCL24/CCR3 impairs the progression and pazopanib resistance of clear cell renal cell carcinoma. Cell Death Dis 11 117 PMID: 32051393

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