SB 366791

Cat. No. 1615 14 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective TRPV1 competitive antagonist

化学名： 4'-Chloro-3-methoxycinnamanilide

纯度： ≥99% (HPLC)

引用文献 (14)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SB 366791

SB 366791 is a potent, selective and competitive vanilloid TRPV1 receptor antagonist (pA₂ = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB₁ and CB₂ receptors, voltage-gated Ca²⁺ channels and the hyperpolarization-activated current (I_h).

许可信息

Sold for research purposes under agreement from GlaxoSmithKline

化合物库 for SB 366791

SB 366791 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SB 366791

分子量	287.75
公式	C₁₆H₁₄ClNO₂
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	472981-92-3
PubChem ID	667594
InChI Key	RYAMDQKWNKKFHD-JXMROGBWSA-N
Smiles	COC1=CC=CC(NC(=O)\C=C\C2=CC=C(Cl)C=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 366791

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	2.88	10
	DMSO	28.77	100

制备储备液 for SB 366791

以下数据基于产品分子量 287.75。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.48 mL	17.38 mL	34.75 mL
5 mM	0.7 mL	3.48 mL	6.95 mL
10 mM	0.35 mL	1.74 mL	3.48 mL
50 mM	0.07 mL	0.35 mL	0.7 mL

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产品说明书 for SB 366791

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SB 366791

参考文献是支持产品生物活性的出版物。

Fowler et al (2003) Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid. Biochem.Pharmacol. 66 757 PMID: 12948856

Gavva et al (2005) Proton activation does not alter antagonist interaction with the capsaicin-binding pocket of TRPV1. Mol.Pharmacol. 68 1524 PMID: 16135784

Gunthorpe et al (2004) Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology 46 133 PMID: 14654105

If you know of a relevant reference for SB 366791, please let us know.

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关键词: SB 366791, SB 366791 supplier, Potent, selective, competitive, TRPV1, VR1, antagonists, Vanillioids, Receptors, TRPV, Channels, Transient, Receptor, Potential, SB366791, GlaxoSmithKline, GSK, 1615, Tocris Bioscience