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SB 3CT

Cat. No. 6088 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： High affinity and selective MMP2 inhibitor
化学名： 2-[[(4-Phenoxyphenyl)sulfonyl]methyl]thiirane
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SB 3CT

SB 3CT is a selective high affinity MMP2 inhibitor (Ki = 28 nM); also inhibits MMP9 (Ki = 400 nM). Active in vivo, neuroprotective and blood-brain barrier permeable.

技术数据 for SB 3CT

分子量 306.4
公式 C15H14O3S2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 292605-14-2
PubChem ID 9883002
InChI Key LSONWRHLFZYHIN-UHFFFAOYSA-N
Smiles O=S(CC1CS1)(C2=CC=C(C=C2)OC3=CC=CC=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SB 3CT

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 30.64 100
ethanol 6.13 20

制备储备液 for SB 3CT

以下数据基于产品分子量 306.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.26 mL 16.32 mL 32.64 mL
5 mM 0.65 mL 3.26 mL 6.53 mL
10 mM 0.33 mL 1.63 mL 3.26 mL
50 mM 0.07 mL 0.33 mL 0.65 mL

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参考文献 for SB 3CT

参考文献是支持产品生物活性的出版物。

Gu et al (2005) A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J.Neurosci. 25 6401 PMID: 16000631

Kleifeld et al (2001) X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzyme. J.Biol.Chem. 18 17125 PMID: 11278946

Gooyit et al (2012) Selective gelatinase inhibitor neuroprotective agents cross the blood-brain barrier. ACS Chem.Neurosci. 3 730 PMID: 23077716

If you know of a relevant reference for SB 3CT, please let us know.

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关键词: SB 3CT, SB 3CT supplier, SB3CT, Selective, high, affinity, MMP2, inhibitors, MMP9, blood-brain, barrier, BBB, permeable, matrix, metalloproteinases, neuroprotective, Matrix, Metalloprotease, 6088, Tocris Bioscience

1 篇 SB 3CT 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SB 3CT 的部分引用包括：

Lin-Chien et al (2021) Role of matrix metalloproteinase-9 in neurodevelopmental deficits and experience-dependent plasticity in Xenopus laevis. Elife 10 PMID: 34282726

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