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SC 236

Cat. No. 3919 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective cyclooxygenase-2 (COX-2) inhibitor
别名： SC 58236
化学名： 4-[5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide
纯度： ≥99% (HPLC)
说明书
引用文献
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SC 236

SC 236 is a selective COX-2 inhibitor (IC50 values are 0.005 and 17.8 μM for COX-2 and COX-1 respectively). Displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision.

许可信息

Sold for research purposes under agreement from Pfizer Inc.

化合物库 for SC 236

SC 236 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for SC 236

分子量 401.79
公式 C16H11ClF3N3O2S
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 170569-86-5
PubChem ID 9865808
InChI Key NSQNZEUFHPTJME-UHFFFAOYSA-N
Smiles ClC(C=C3)=CC=C3C1=CC(C(F)(F)F)=NN1C2=CC=C(S(=O)(N)=O)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SC 236

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 40.18 100
ethanol 40.18 100

制备储备液 for SC 236

以下数据基于产品分子量 401.79。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.49 mL 12.44 mL 24.89 mL
5 mM 0.5 mL 2.49 mL 4.98 mL
10 mM 0.25 mL 1.24 mL 2.49 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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参考文献 for SC 236

参考文献是支持产品生物活性的出版物。

Gierse et al (1996) A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J.Biol.Chem. 271 15810 PMID: 8663121

Roche-Nagle et al (2004) Antimetastatic activity of a cyclooxygenase-2 inhibitor. Br.J.Cancer 91 359 PMID: 15213717

Penning et al (1997) Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib). J.Med.Chem. 40 1347 PMID: 9135032

If you know of a relevant reference for SC 236, please let us know.

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关键词: SC 236, SC 236 supplier, SC236, SC58236, selective, cyclooxygenase-2, COX-2, inhibitors, inhibits, Pfizer, SC, 58236, Cyclooxygenase, 3919, Tocris Bioscience

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