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SCH 336

Cat. No. 5815 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Highly potent and selective CB2 inverse agonist
化学名： N-[(1S)-1-[4-[[4-Methoxy-2-[(4-methoxyphenyl)sulfonyl]phenyl]sulfonyl]phenyl]ethyl]methanesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SCH 336

SCH 336 is a highly potent and selective CB2 receptor inverse agonist (Ki = 1.8 nM, EC50 = 2 nM). Displays 100-fold selectivity for CB2 receptors over CB1. Increases Forskolin stimulated cAMP accumulation in CHO cells expressing human CB2 receptors. Inhibits leukocyte migration in a murine model of delayed-type hypersensitivity and inhibits antigen-induced lung eosinophilia in a mouse allergy model.

化合物库 for SCH 336

SCH 336 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SCH 336

分子量 539.64
公式 C23H25NO8S3
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 447459-51-0
PubChem ID 10324989
InChI Key NXODIUKWAVUFGF-INIZCTEOSA-N
Smiles CS(N[C@@H](C)C1=CC=C(S(C2=C(S(=O)(C3=CC=C(OC)C=C3)=O)C=C(OC)C=C2)(=O)=O)C=C1)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SCH 336

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 53.96 100

制备储备液 for SCH 336

以下数据基于产品分子量 539.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.27 mL 18.53 mL
5 mM 0.37 mL 1.85 mL 3.71 mL
10 mM 0.19 mL 0.93 mL 1.85 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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参考文献 for SCH 336

参考文献是支持产品生物活性的出版物。

Lunn et al (2006) A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo. J.Pharmacol.Exp.Ther. 316 780 PMID: 16258021

If you know of a relevant reference for SCH 336, please let us know.

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关键词: SCH 336, SCH 336 supplier, SCH336, potent, selective, cannabinoid, 2, receptor, CB2, inverse, agonists, Receptors, 5815, Tocris Bioscience

1 篇 SCH 336 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SCH 336 的部分引用包括：

Dos-Santos-Pereira et al (2020) Cannabidiol prevents LPS-induced microglial inflammation by inhibiting ROS/NF-κB-dependent signaling and glucose consumption. Glia 68 561 PMID: 31647138

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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