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Submit ReviewSDZ SER 082 fumarate
说明： Selective 5-HT2B/2C antagonist
化学名： (+)-cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine fumarate
生物活性 for SDZ SER 082 fumarate
SDZ SER 082 fumarate is a selective 5-HT2B/2C receptor antagonist with low affinity for 5-HT1A receptors. Inhibits [3H]-mesulergine binding to 5-HT2C receptors with a pKD of 7.8. Inhibits 5-HT2B mediated responses in the rat fundus (pKB = 7.34).
许可信息
Sold with the permission of Novartis Pharma AG
技术数据 for SDZ SER 082 fumarate
| 分子量 | 344.41 |
| 公式 | C15H20N2.C4H4O4 |
| 储存 | Store at RT |
| CAS Number | 1417343-80-6 |
| PubChem ID | 45073480 |
| InChI Key | DXUZZRDHJMOLTN-MRYVXRNOSA-N |
| Smiles | C(\C=C\C(O[H])=O)(O[H])=O.[H][C@@]23[C@@](CCN(C3)C)([H])CN(CC4)C1=C4C=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SDZ SER 082 fumarate
参考文献 for SDZ SER 082 fumarate
参考文献是支持产品生物活性的出版物。
Kalkman et al (1998) Cataleptogenic effect of subtype selective 5-HT receptor antagonists in the rat. Eur.J.Pharmacol. 343 201 PMID: 9570468
Mora et al (1997) Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze. Pharmacol.Biochem.Behav. 58 1051 PMID: 9408213
Nozulak et al (1995) (+)-cis 4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]-naphthyridine: a 5-HT2C/2B receptor antagonist with low 5-HT2A receptor affinity. J.Med.Chem. 38 28 PMID: 7837236
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关键词: SDZ SER 082 fumarate, SDZ SER 082 fumarate supplier, Selective, 5-HT2B/2C, antagonists, Serotonin, Receptors, SDZSER, fumarate082, SDZSER082, 5-HT2B, 5-HT2C, 1255, Tocris Bioscience
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5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.