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SDZ WAG 994

Cat. No. 2465 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective A1 agonist
化学名： N-Cyclohexyl-2'-O-methyladenosine
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SDZ WAG 994

SDZ WAG 994 is a potent and selective A1 adenosine receptor agonist (Ki values are 23, > 10000 and 25000 nM for A1, A2A and A2B receptors respectively). Causes a sustained fall in blood pressure and heart rate in spontaneous hypertensive rats and inhibits adenosine deaminase-stimulated lipolysis in rat adipocytes (Ki = 8 nM).

化合物库 for SDZ WAG 994

SDZ WAG 994 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SDZ WAG 994

分子量 363.41
公式 C17H25N5O4
储存 Desiccate at +4°C
纯度 ≥99% (HPLC)
CAS Number 130714-47-5
PubChem ID 164305
InChI Key JAKAFSGZUXCHLF-LSCFUAHRSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N(C=N4)C2=C4C(NC3CCCCC3)=NC=N2)[C@@H]1OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SDZ WAG 994

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1.1eq. NaOH 36.34 100
DMSO 36.34 100

制备储备液 for SDZ WAG 994

以下数据基于产品分子量 363.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.76 mL 27.52 mL
5 mM 0.55 mL 2.75 mL 5.5 mL
10 mM 0.28 mL 1.38 mL 2.75 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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参考文献 for SDZ WAG 994

参考文献是支持产品生物活性的出版物。

Ishikawa et al (1998) Hypoglycemic and hypotensive effects of 6-cyclohexyl-2'-O-methyl-adenosine, an adenosine A1 receptor agonist, in spontaneous hypertensive rat complicated with hyperglycemia. Diabetes Res.Clin.Pract. 39 3 PMID: 9597368

Jacobson and Gao (2006) Adenosine receptors as therapeutic targets. Nat.Rev.Drug Discov. 5 247 PMID: 16518376

Wagner et al (1995) General pharmacology of SDZ WAG 994, a potent selective and orally active adenosine A1 receptor agonist. Drug Dev.Res. 34 276

If you know of a relevant reference for SDZ WAG 994, please let us know.

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关键词: SDZ WAG 994, SDZ WAG 994 supplier, Potent, selective, A1, agonists, Receptors, adenosines, SDZWAG994, Adenosine, 2465, Tocris Bioscience

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