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说明： Selective prostacyclin IP1 receptor agonist
别名： NS-304,ACT-293987
化学名： 2-[4-[(5,6-Diphenyl-2-pyrazinyl)(1-methylethyl)amino]butoxy]-N-(methylsulfonyl)acetamide
纯度： ≥98% (HPLC)
生物活性 for Selexipag
Selexipag is a selective prostacyclin IP1 receptor agonist (Ki values are 260 and 2100 nM and for human and rat IP receptors, and >10 μM for EP1-4, DP, FP, and TP receptors). Prodrug for the active form of MRE 269. Ameliorates vascular endothelial dysfunction and increases femoral skin blood flow in rats. Orally available.
许可信息
Sold with the permission of Nippon Shinyaku Co.
化合物库 for Selexipag
Selexipag is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Selexipag
| 分子量 | 496.62 |
| 公式 | C26H32N4O4S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 475086-01-2 |
| PubChem ID | 9913767 |
| InChI Key | QXWZQTURMXZVHJ-UHFFFAOYSA-N |
| Smiles | CC(C)N(CCCCOCC(NS(C)(=O)=O)=O)C1=NC(C3=CC=CC=C3)=C(C2=CC=CC=C2)N=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Selexipag
参考文献 for Selexipag
参考文献是支持产品生物活性的出版物。
Kuwano et al (2007) 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug. J.Pharmacol.Exp.Ther. 322 1181 PMID: 17545310
Kuwano et al (2008) A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses of its active fo J.Pharmacol.Exp.Ther. 326 691 PMID: 18552131
Morrison et al (2010) Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function. J.Pharmacol.Exp.Ther. 335 249 PMID: 20660124
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关键词: Selexipag, Selexipag supplier, NS304, Selexipag, agonists, prostaglandin, PGI2, analogue, IP, receptors, hypertension, vascular, supplier, NS-304, ACT-293987, Prostanoid, Receptors, 3351, Tocris Bioscience
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