主页 / 药理学 / Enzyme-Linked Receptors / Receptor Tyrosine Kinases (RTKs) / Other RTKs / Other RTKs Inhibitors / Selpercatinib

Selpercatinib

Cat. No. 7696 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective RET inhibitor
化学名： 6-(2-Hydroxy-2-methylpropoxy)-4-[6-[6-[(6-methoxy-3-pyridinyl)methyl]-3,6-diazabicyclo[3.1.1]hept-3-yl]-3-pyridinyl]pyrazolo[1,5-a]pyridine-3-carbonitrile
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Selpercatinib

Selpercatinib, is a potent and selective receptor tyrosine kinase RET inhibitor (EC50 = 4 nM). It shows > 100-fold selectivity for > 95% of 228 purified kinase domains in radiometric assays. In vitro, it inhibits proliferation of cancer cell lines containing RET mutations or gene fusions. In vivo, it inhibits tumor growth in diverse RET mouse models. Selpercatinib is orally bioavailable.

化合物库 for Selpercatinib

Selpercatinib is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Selpercatinib

分子量 525.6
公式 C29H31N7O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2152628-33-4
PubChem ID 134436906
InChI Key XIIOFHFUYBLOLW-UHFFFAOYSA-N
Smiles N#CC=1C=NN2C=C(OCC(O)(C)C)C=C(C=3C=NC(=CC3)N4CC5N(CC6=CN=C(OC)C=C6)C(C4)C5)C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Selpercatinib

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 10.51 20

制备储备液 for Selpercatinib

以下数据基于产品分子量 525.6。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 9.51 mL 47.56 mL 95.13 mL
1 mM 1.9 mL 9.51 mL 19.03 mL
2 mM 0.95 mL 4.76 mL 9.51 mL
10 mM 0.19 mL 0.95 mL 1.9 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for Selpercatinib

参考文献是支持产品生物活性的出版物。

Subbiah et al (2018) Selective RET kinase inhibition for patients with RET-altered cancers. Ann.Oncol. 29 1869 PMID: 29912274

Brandhuber et al (2016) The development of LOXO-292, a potent, KDR/VEGFR2-sparing RET kinase inhibitor for treating patients with RET-dependent cancers. International Conference on Molecular Targets and Cancer Therapeutics

If you know of a relevant reference for Selpercatinib, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Other RTKs Inhibitors

关键词: Selpercatinib, Selpercatinib supplier, RET, tyrosine, kinases, selective, potent, inhibitors, inhibits, orally, bioavailable, Other, RTKs, 7696, Tocris Bioscience

篇 Selpercatinib 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Selpercatinib 的引用文献。 您是否知道使用了 Tocris Selpercatinib 的优秀论文？ 请告知我们.

Selpercatinib 的评论

目前没有该产品的评论。 Be the first to review Selpercatinib and earn rewards!

Have you used Selpercatinib?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review