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Discontinued Product
4441 has been discontinued.
说明： α7 nAChR agonist; also histamine H3 antagonist
别名： WAY 317538
化学名： N-[4-(3-pyridinyl)phenyl]-4-morpholinepentanamide
纯度： ≥99% (HPLC)
生物活性 for SEN 12333
SEN 12333 is a α7 nicotinic acetylcholine receptor (nAChR) agonist (EC50 = 1.6 μM, Ki = 260 nM at rat α7 nAChRs). Also displays functional antagonism at histamine H3 receptors (IC50 = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs (IC50 = 8.5 μM). Neuroprotective in a rodent model of quisqualic acid-induced cholinergic degeneration. Brain penetrant and orally bioavailable.
技术数据 for SEN 12333
| 分子量 | 339.43 |
| 公式 | C20H25N3O2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 874450-44-9 |
| PubChem ID | 45484303 |
| InChI Key | XCHIZTUBUXZESJ-UHFFFAOYSA-N |
| Smiles | O=C(CCCCN3CCOCC3)NC(C=C2)=CC=C2C1=CC=CN=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SEN 12333
参考文献 for SEN 12333
参考文献是支持产品生物活性的出版物。
Roncarati et al (2009) Procognitive and neuroprotective activity of a novel α7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders. J.Pharmacol.Exp.Ther. 329 459 PMID: 19223665
Beinat et al (2012) Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. Bioorg.Med.Chem.Lett. 22 2380 PMID: 22410083
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关键词: SEN 12333, SEN 12333 supplier, SEN12333, WAY317538, WAY, 317538, alpha7, a7, α7, nicotinic, acetylcholine, receptors, nAChR, agonists, histamine, h3, functional, antagonists, brain, penetrant, orally, bioavailable, Nicotinic, (a7), Receptors, Histamine, H3, 4441, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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