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Sephin 1

Cat. No. 5553 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1
化学名： (2E)-2-[(2-Chlorophenyl)methylene]-hydrazinecarboximidamide carbonic acid salt
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Sephin 1

Sephin 1 is an inhibitor of the regulatory subunit PPP1R15A of protein phosphatase 1. Does not bind PPP1R15B or have α2 adrenergic agonist activity. Cytoprotective in endoplasmic reticulum stressed cells in vitro. Prevents defects associated with protein misfolding in a mouse Charcot-Marie Tooth-1B model. Orally available.

化合物库 for Sephin 1

Sephin 1 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Sephin 1

分子量 258.66
公式 C8H9ClN4.CH2O3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1883549-35-6
PubChem ID 121513868
InChI Key LCQVFBONUDQAEH-NKPNRJPBSA-N
Smiles ClC1=C(/C=N/NC(N)=N)C=CC=C1.OC(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Sephin 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 25.87 100

制备储备液 for Sephin 1

以下数据基于产品分子量 258.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.87 mL 19.33 mL 38.66 mL
5 mM 0.77 mL 3.87 mL 7.73 mL
10 mM 0.39 mL 1.93 mL 3.87 mL
50 mM 0.08 mL 0.39 mL 0.77 mL

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参考文献 for Sephin 1

参考文献是支持产品生物活性的出版物。

Das et al (2015) Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science 348 239 PMID: 25859045

If you know of a relevant reference for Sephin 1, please let us know.

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关键词: Sephin 1, Sephin 1 supplier, Sephin1, protein, phosphatases, 1, PPP1R115A, serine/threonine, folding, Charcot-Marie, Tooth, 1B, CMT1B, inhibitors, orally, available, inhibits, 951441-04-6, Protein, Ser/Thr, Phosphatases, 5553, Tocris Bioscience

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