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SET 2

Cat. No. 6990 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective TRPV2 antagonist
化学名： N-(2-Furanylmethyl)-3-[[4-(methylpropylamino)-6-(trifluoromethyl)-2-pyrimidinyl]thio]propanamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SET 2

SET 2 is a TRPV2 (transient receptor potential vanilloid type 2) antagonist (IC50 = 0.46 μM). Selective for TRPV2 over TRPV1, TRPV3 and TRPV4 expressed in HEK293 cells. Inhibits lyosphosphatidic acid (LPA)-induced prostate cancer cell migration in vitro.

化合物库 for SET 2

SET 2 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SET 2

分子量 402.44
公式 C17H21F3N4O2S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2313525-20-9
InChI Key LZHSWRWIMQRTOP-UHFFFAOYSA-N
Smiles CCCN(C1=NC(SCCC(NCC2=CC=CO2)=O)=NC(C(F)(F)F)=C1)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SET 2

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 40.24 100
ethanol 20.12 50

制备储备液 for SET 2

以下数据基于产品分子量 402.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.48 mL 12.42 mL 24.85 mL
5 mM 0.5 mL 2.48 mL 4.97 mL
10 mM 0.25 mL 1.24 mL 2.48 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

Molarity Calculator

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Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Dilution Calculator

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参考文献 for SET 2

参考文献是支持产品生物活性的出版物。

Chai et al (2019) Structure-based discovery of a subtype-selective inhibitor targeting a transient receptor potential vanilloid channel. J.Med.Chem. 62 1373 PMID: 30620187

If you know of a relevant reference for SET 2, please let us know.

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关键词: SET 2, SET 2 supplier, SET2, TRPV2, antagonist, antagonists, antagonism, transient, receptor, potential, vanilloid, metastasis, cell, migration, subtype, selective, TRPV, 6990, Tocris Bioscience

1 篇 SET 2 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SET 2 的部分引用包括：

Yaniv et al (2023) The Effect of Cannabis Plant Extracts on Head and Neck Squamous Cell Carcinoma and the Quest for Cannabis-Based Personalized Therapy. Cancers (Basel) 15 PMID: 36672446

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