SEW 2871

Cat. No. 2284 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Cell-permeable, selective S1P₁ receptor agonist

化学名： 5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]1,2,4-oxadiazole

纯度： ≥99% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for SEW 2871

SEW 2871 is a novel, potent and selective sphingosine-1-phosphate 1 (S1P₁) receptor agonist. Activates S1P₁ receptor with an EC₅₀ of 13 nM, but does not activate S1P₂, S1P₃, S1P₄ or S1P₅ receptors at concentrations up to 10 μM. Cell-permeable and active in vivo.

技术数据 for SEW 2871

分子量	440.36
公式	C₂₀H₁₀F₆N₂OS
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	256414-75-2
PubChem ID	4077460
InChI Key	OYMNPJXKQVTQTR-UHFFFAOYSA-N
Smiles	FC(F)(F)C1=C(C=C(S1)C1=NC(=NO1)C1=CC(=CC=C1)C(F)(F)F)C1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SEW 2871

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	8.81	20
	ethanol	8.81	20

制备储备液 for SEW 2871

以下数据基于产品分子量 440.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	11.35 mL	56.77 mL	113.54 mL
1 mM	2.27 mL	11.35 mL	22.71 mL
2 mM	1.14 mL	5.68 mL	11.35 mL
10 mM	0.23 mL	1.14 mL	2.27 mL

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产品说明书 for SEW 2871

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SEW 2871

参考文献是支持产品生物活性的出版物。

Hale et al (2004) A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists. J.Med.Chem. 47 6662 PMID: 15615513

Sanna et al (2004) Sphingosine 1-phosphate (S1P) receptor subtypes S1P₁ and S1P₃, respectively, regulate lymphocyte recirculation and heart rate. J.Biol.Chem. 279 13839 PMID: 14732717

Bolick et al (2005) Sphingosine-1-phosphate prevents tumor necrosis factor-α-mediated monocyte adhesion to aortic endothelium in mice. Arterioscler.Thromb.Vasc.Biol. 25 976 PMID: 15761190

If you know of a relevant reference for SEW 2871, please let us know.

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Sphingosine-1-Phosphate Receptors

关键词: SEW 2871, SEW 2871 supplier, Cell-permeable, selective, S1P1, receptors, agonists, EDG1, sphingosine-1-phosphate, SEW2871, Sphingosine-1-phosphate, Receptors, 2284, Tocris Bioscience