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SGX 523

Cat. No. 5356 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective and potent c-MET kinase inhibitor
化学名： 6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SGX 523

SGX 523 is a potent and selective c-MET kinase inhibitor (IC50 = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 μM). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells.

External Portal Information for SGX 523

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGX 523 is reviewed on the chemical probes website.

化合物库 for SGX 523

SGX 523 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for SGX 523

分子量 359.41
公式 C18H13N7S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1022150-57-7
PubChem ID 24779724
InChI Key BCZUAADEACICHN-UHFFFAOYSA-N
Smiles CN1N=CC(C(C=C2)=NN3C2=NN=C3SC4=CC5=CC=CN=C5C=C4)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SGX 523

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 7.19 20

制备储备液 for SGX 523

以下数据基于产品分子量 359.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 13.91 mL 69.56 mL 139.12 mL
1 mM 2.78 mL 13.91 mL 27.82 mL
2 mM 1.39 mL 6.96 mL 13.91 mL
10 mM 0.28 mL 1.39 mL 2.78 mL

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参考文献 for SGX 523

参考文献是支持产品生物活性的出版物。

Buchanan et al (2009) SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol.Cancer.Ther. 8 3181 PMID: 19934279

If you know of a relevant reference for SGX 523, please let us know.

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关键词: SGX 523, SGX 523 supplier, SGX523, Selective, potent, c-MET, kinase, inhibitors, inhibits, MET, Receptors, 5356, Tocris Bioscience

2 篇 SGX 523 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SGX 523 的部分引用包括：

Ortega et al (2017) Adhesion to the host cell surface is sufficient to mediate Listeria monocytogenes entry into epithelial cells. Mol Biol Cell 28 2945 PMID: 28877987

Bastounis et al (2018) Matrix stiffness modulates infection of endothelial cells by Listeria monocytogenes via expression of cell surface vimentin. Mol Biol Cell 29 1571 PMID: 29718765

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