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说明： Selective Neuropeptide S receptor antagonist
化学名： N-[(4-Fluorophenyl)methyl]tetrahydro-3-oxo-1,1-diphenyl-3H-oxazolo[3,4-a]pyrazine-7(1H)-carboxamide
纯度： ≥98% (HPLC)
生物活性 for SHA 68
SHA 68 is a selective neuropeptide S receptor (NPSR) antagonist (IC50 values are 22.0 and 23.8 nM for human NPSR Asn107 and Ile107 variants respectively). Displays no activity against a range of 14 GPCRs, including vasopressin and oxytocin receptors.
化合物库 for SHA 68
SHA 68 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for SHA 68
| 分子量 | 445.49 |
| 公式 | C26H24FN3O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 847553-89-3 |
| PubChem ID | 11374217 |
| InChI Key | SFRQIPRTNYHJHP-UHFFFAOYSA-N |
| Smiles | O=C(NCC4=CC=C(F)C=C4)N1CC2N(C(OC(C5=CC=CC=C5)2C3=CC=CC=C3)=O)CC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SHA 68
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 44.55 | 100 | |
| ethanol | 44.55 | 100 |
制备储备液 for SHA 68
以下数据基于产品分子量 445.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.24 mL | 11.22 mL | 22.45 mL |
| 5 mM | 0.45 mL | 2.24 mL | 4.49 mL |
| 10 mM | 0.22 mL | 1.12 mL | 2.24 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.45 mL |
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产品说明书 for SHA 68
参考文献 for SHA 68
参考文献是支持产品生物活性的出版物。
Okamura et al (2008) Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor. J.Pharmacol.Exp.Ther. 325 893 PMID: 18337476
Okamura et al (2011) Neuropeptide S enhances memory during the consolidation phase and interacts with noradrenergic systems in the brain. Neuropsychopharmacology 36 744 PMID: 21150909
Trapella et al (2011) Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68). J.Med.Chem. 54 2738 PMID: 21466221
If you know of a relevant reference for SHA 68, please let us know.
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关键词: SHA 68, SHA 68 supplier, SHA68, neuropeptides, S, NPSRs, NPS, antagonists, selective, Neuropeptide, Receptors, 4510, Tocris Bioscience
2 篇 SHA 68 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SHA 68 的部分引用包括：
Jing et al (2020) Neuropeptide S Displays as a Key Neuromodulator in Olfactory Spatial Memory. Chem Senses 45 195-202 PMID: 32010937
Ruzza et al (2018) Pharmacological profile of the neuropeptide S receptor: Dynamic mass redistribution studies. Pharmacol Res Perspect 6 e00445 PMID: 30534379
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