Sildenafil citrate

Cat. No. 3784 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent PDE5 inhibitor; orally active

化学名： 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate

纯度： ≥99% (HPLC)

引用文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Sildenafil citrate

Sildenafil citrate is an orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC₅₀ = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro. Sildenafil citrate promotes mobilization of hematopoietic stem cells (HSCs) in combination with AMD 3100 (Cat. No. 3299). Reduces pulmonary pressure and edema.

化合物库 for Sildenafil citrate

Sildenafil citrate is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Sildenafil citrate

分子量	666.7
公式	C₂₂H₃₀N₆O₄S.C₆H₈O₇
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	171599-83-0
PubChem ID	135413523
InChI Key	DEIYFTQMQPDXOT-UHFFFAOYSA-N
Smiles	O=C(O)C(O)(CC(O)=O)CC(O)=O.CN1CCN(S(C2=CC=C(OCC)C(C(NC4=C3N(C)N=C4CCC)=NC3=O)=C2)(=O)=O)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Sildenafil citrate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	66.67	100

制备储备液 for Sildenafil citrate

以下数据基于产品分子量 666.7。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.5 mL	7.5 mL	15 mL
5 mM	0.3 mL	1.5 mL	3 mL
10 mM	0.15 mL	0.75 mL	1.5 mL
50 mM	0.03 mL	0.15 mL	0.3 mL

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产品说明书 for Sildenafil citrate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Sildenafil citrate

参考文献是支持产品生物活性的出版物。

Ballard et al (1998) Effects of silde. on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J.Urol. 159 2164 PMID: 9598563

Turko et al (1999) Inhibition of cyclic cGMP-binding cyclic GMP-specific phosphodiesterase (type 5) by silde. and related compounds. Mol.Pharmacol. 56 124 PMID: 10385692

Ghofrani et al (2006) Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat.Rev.Drug Discov. 5 689 PMID: 16883306

Smith-Berdan et al (2019) Viagra enables efficient, single-day hematopoietic stem cell mobilization. Stem Cell Reports. PMID: 31607567

If you know of a relevant reference for Sildenafil citrate, please let us know.

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关键词: Sildenafil citrate, Sildenafil citrate supplier, phosphodiesterases, 5, PDE5, inhibitors, inhibits, orally, active, potent, HSC, hematopoietic, haematopoietic, stem, cells, mobilization, COVID-19, pulmonary, edema, Phosphodiesterases, Stem, Cell, Proliferation, Hematopoietic, Cells, 3784, Tocris Bioscience

2 篇 Sildenafil citrate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Sildenafil citrate 的部分引用包括：

Vandendriessche et al (2013) The soluble guanylate cyclase activator BAY 58-2667 protects against morbidity and mortality in endotoxic shock by recoupling organ systems. Development 8 e72155 PMID: 24015214

Xiaofeng et al (2021) Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage. Cell Chem Biol 28 1669-1678.e5 PMID: 34166610

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